Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Isolation and Characterization of Antidermatophytic Bioactive Molecules from Piper longum L. Leaves Subject The topic of the resource Activity-guided fractionation; Antidermatophytic bioactive molecules; Piper longum Description An account of the resource Piper longum L. (Piperaceae) commonly known as "long pepper" is a well known medicinal plant in ayurveda. Different parts of this plant, such as root, seed, fruit, whole plant etc. are used traditionally in various ailments. Here we have investigated the antidermatophytic activity of sequentially extracted petroleum ether, chloroform, methanol and water extracts from P. longum leaf against Trichophytonmentagrophytes, T. rubrum, T. tonsurans, Microsporum fulvum and M. gypseum. Better activity of chloroform and methanol extracts was observed. The chloroform extract was selected for further study and the MIC value was recorded as 5.0 mg ml-1 against the test organisms. In the chloroform extract, tannins and phenolic compounds were detected. Further activity-guided fractionation of chloroform extract by silica gel column chromatography yielded nine major fractions. Among these, fraction-1, 4, 5 and 7 showed higher antidermatophytic activity. Fraction-4 on further purification by repeated column chromatography yielded a potential antidermatophytic fraction showing MIC value of 0.625 mg ml-1 against T. mentagrophytes and T. rubrum as determined by broth microdilution method. The major compounds were identified as 1,2-benzenedicarboxylic acid, bis(2-ethylhexyl) ester (C24H38O4] (41.45 %), 2,2-dimethoxybutane (C6H14O2] (13.6 %) and ?-myrcene (C10H16) (6.75 %) based on GC-MS data. 2012 Association of Microbiologists of India. Creator An entity primarily responsible for making the resource Das J.; Jha D.K.; Policegoudra R.S.; Mazumder A.H.; Das M.; Chattopadhyay P.; Singh L. Source A related resource from which the described resource is derived Indian Journal of Microbiology, Vol-52, No. 4, pp. 624-629. Date A point or period of time associated with an event in the lifecycle of the resource 2012-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s12088-012-0303-x" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s12088-012-0303-x</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870789502&amp;doi=10.1007%2Fs12088-012-0303-x&amp;partnerID=40&amp;md5=8e1de1363f7635b3c6beba39075be195" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870789502&amp;doi=10.1007%2fs12088-012-0303-x&amp;partnerID=40&amp;md5=8e1de1363f7635b3c6beba39075be195</a> Rights Information about rights held in and over the resource All Open Access; Green Open Access Relation A related resource ISSN: 468991; CODEN: IJMBA Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Das J., Defence Research Laboratory, Tezpur, 784001 Assam, Post Bag No. 2, India; Jha D.K., Microbial Ecology Laboratory, Department of Botany, Gauhati University, Guwahati, 781014 Assam, India; Policegoudra R.S., Defence Research Laboratory, Tezpur, 784001 Assam, Post Bag No. 2, India; Mazumder A.H., Defence Research Laboratory, Tezpur, 784001 Assam, Post Bag No. 2, India; Das M., Christ University, Bangalore, 560029 Karnataka, India; Chattopadhyay P., Defence Research Laboratory, Tezpur, 784001 Assam, Post Bag No. 2, India; Singh L., Defence Research Laboratory, Tezpur, 784001 Assam, Post Bag No. 2, India