Gold NP; Multidrug resistance; NVs; Superbugs; virus like particle (VLP)
Superbugs pose a serious threat to humans as many of the currently available antibiotics are not effective in treating the diseases inflicted by these microbes.Among the different bacteria causing clinical infections, Klebsiella pneumoniae, Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa, Staphylococcusaureus, Proteus mirabilis, and so on, are some of the most vicious ones emergingat an unprecedented rate with huge impact on public health. In this context, prophylacticmeasures for these diseases assume great significance and NVs indeedfit in as a promising measure. Sustained release, improved antigen stability, betterimmunogenicity, better access to lymph nodes and low minimum immunotoxicitytranslates to the better efficacy of nano-based vaccines. Lipid-based NP (nanoparticles),dendrimers, Polymeric NP, self-assembled peptide NP, virus like particles(VLPs), and so on, are the promising NV (nanovaccines) delivery approaches.Improvisations of NVs by decorating NP surfaces with ligands that target specificimmune cells like the dendritic cells is also a promising approach to induce both Tand B cell responses. The current review focuses on the breakthroughs in the NVdomain with the challenges and opportunities of creating NVs to curb the menaceof superbugs. 2022 Scrivener Publishing LLC. All rights reserved.
Santhosh S.K.; Kootery K.P.; Umesh M.; Alex P.M.; Mani M.; Roy A.; Sarojini S.
Nanovaccinology as Targeted Therapeutics, pp. 53-76.
Santhosh S.K., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Kootery K.P., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Umesh M., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Alex P.M., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Mani M., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Roy A., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Sarojini S., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India