Three-component p-TSA catalyzed synthesis of hydrazinyl thiazole derivatives

Title

Three-component p-TSA catalyzed synthesis of hydrazinyl thiazole derivatives

Creator

Kumar S.L.; Chundattu S.J.; Govindaraju S.; Tabassum S.

Description

A direct single-pot three-component procedure for synthesizing bio-active hydrazinyl thiazole derivatives has been demonstrated. The reaction involves substituted 2-Bromoacetophenones, carboxaldehydes, and thiosemicarbazide to form the hydrazinyl thiazole scaffolds via a simple condensation reaction followed by intramolecular cyclization with p-TSA as a catalyst at room temperature. The ease of product separation, lack of column chromatographic purification, and use of readily available starting materials result in an efficient approach for organic synthesis. 2023 Elsevier Ltd. All rights reserved.

Source

Materials Today: Proceedings, Vol-100, pp. 182-187.

Date

2023-01-01

Publisher

Elsevier Ltd

Subject

Hyrazinyl thiazole; Multicomponent; p-TSA; Single-Pot; Three-component

Coverage

Kumar S.L., Department of Chemistry, CHRIST, Deemed to be University, Bengaluru, 570029, India; Chundattu S.J., Department of Sciences and Humanities, CHRIST, Deemed to be University, Bengaluru, 570029, India; Govindaraju S., Department of Sciences and Humanities, CHRIST, Deemed to be University, Bengaluru, 570029, India; Tabassum S., Department of Chemistry, Surana College, South End Road, Basavanagudi, Bengaluru, 560004, India

Rights

Restricted Access

Relation

ISSN: 22147853

Format

Online

Language

English

Type

Conference paper

Identifier

https://doi.org/10.1016/j.matpr.2023.06.101

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214212640&doi=10.1016%2fj.matpr.2023.06.101&partnerID=40&md5=74e522d6e5de81f90c6ae4cdefc1852f