Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Conference Papers Conference Paper Faculty Publications- Conference Papers Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Early detection of breast cancer using ER specific novel NIR fluorescent dye conjugate: A phantom study using FD-f-DOT system Subject The topic of the resource Breast cancer; Diffuse optical tomography; Estrogen receptors; Fluorescence; Fluorescent dye; Target specific Description An account of the resource Fluorescence diffuse optical tomography (f-DOT) is an imaging technique that can quantify the spatial distribution of fluorescent tracers in small animals and human soft tissues. Efficacy of f-DOT imaging can be improved by tagging a functional group to the dye. A novel estrogen receptor (ER) specific near-infrared (NIR) fluorescent dye conjugate was synthesized which can be effectively used for detecting breast cancer tissues at an early stage. Our novel dye, Near Infrared Dye Conjugate-2 (NIRDC-2), is a conjugate of 17?-estradiol with an analogue of Indocyanine Green dye, bis1,1-(4-sulfobutyl) indotricarbocyanine-5-carboxylic acid, sodium salt. Our present study focuses on imaging cylindrical silicone phantoms using Frequency Domain f-DOT system. Background absorption and scattering coefficients were 0.01mm-1 and 1mm-1 respectively. 10?M concentration of NIRDC-2 and Indocyanine Green (ICG) were administered separately into a cylindrical hole (target) of size 8mm diameter in the phantom. In-silico studies were performed to analyze the properties of dyes using experimental data. Absorption coefficient of 0.0002 mm-1 was recovered for the background. Fluorophore absorption coefficient at the target recovered were 0.000173 mm-1 and 0.000408 mm-1 for ICG and NIRDC-2 respectively. In comparison with ICG, our novel dye had a two fold higher target to background contrast. Recovered target position was accurate but size altered. In concurrence with the recovered fluorescent property and the cell lines studies carried out earlier, binding properties of NIRDC-2 makes it a potential probe for the early tumor detection using f-DOT system. COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only. Creator An entity primarily responsible for making the resource Pillai V.J.; Jose I.; Ramachandran H. Source A related resource from which the described resource is derived Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol-10874 Publisher An entity responsible for making the resource available SPIE Date A point or period of time associated with an event in the lifecycle of the resource 2019-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1117/12.2510169" target="_blank" rel="noreferrer noopener">https://doi.org/10.1117/12.2510169</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064827844&amp;doi=10.1117%2F12.2510169&amp;partnerID=40&amp;md5=414e4687058036c85f5c250d42d37654" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064827844&amp;doi=10.1117%2f12.2510169&amp;partnerID=40&amp;md5=414e4687058036c85f5c250d42d37654</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 16057422; ISBN: 978-151062390-3 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Conference paper Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pillai V.J., Faculty of Engineering, CHRIST Deemed to Be University, Bangalore, 560074, India; Jose I., Faculty of Engineering, CHRIST Deemed to Be University, Bangalore, 560074, India; Ramachandran H., Raman Research Institute, Bangalore, 5600, India