Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Conference Papers Conference Paper Faculty Publications- Conference Papers Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Computationally efficient wavelet domain solver for florescence diffuse optical tomography Subject The topic of the resource Estrogen receptor; Inverse solving; Multi-resolution; NIRf dye; Parallel processing; Wavelet transform Description An account of the resource Estrogen induced proliferation of mutant cells is a growth signal hallmark of breast cancer. Fluorescent molecule that can tag Estrogen Receptor (ER) can be effectively used for detecting cancerous tissue at an early stage. A novel targetspecific NIRf dye conjugate aimed at measuring ER status was synthesized by ester formation between 17-? estradiol and a hydrophilic derivative of ICG, cyanine dye, bis-1,1-(4-sulfobutyl) indotricarbocyanine-5-carboxylic acid, sodium salt. In-vitro studies provided specific binding on ER+ve [MCF-7] cells clearly indicating nuclear localization of the dye for ER+ve as compared to plasma level staining for MDAMB-231. Furthermore, cancer prone cells showed 4.5-fold increase in fluorescence signal intensity compared to control.; A model of breast phantom was simulated to study the in-vivo efficiency of dye with the parameters of dye obtained from photo-physical and in-vitro studies. The excitation (754 nm) and emission (787 nm) equation are solved independently using parallel processing strategies. The results were obtained by carrying out wavelet transformation on forward and the inverse data sets. An improvisation of the Information content of system matrix was suggested in wavelet domain. The inverse problem was addressed using LevenbergMarquardt (LM) procedure with the minimization of objective function using Tikhonov approach. The multi resolution property of wavelet transform was explored in reducing error and increasing computational efficiency. Our results were compared with the single resolution approach on various parameters like computational time, error function, and Normalized Root Mean Square (NRMS) error. A model with background absorption coefficient of 0.01 mm-1 with anomalies of 0.02 mm-1 with constant reduced scattering of 2.0 mm for different concentration of dye was compared in the result. The reconstructed optical properties were in concurrence with the tissue property at 787 nm. We intend our future plans on in-vivo study on developing a complete instrumentation for imaging a target specific lipophilic dye. Springer International Publishing Switzerland 2014. Creator An entity primarily responsible for making the resource Francis K.J.; Jose I. Source A related resource from which the described resource is derived Springer Proceedings in Mathematics and Statistics, Vol-92, pp. 457-469. Publisher An entity responsible for making the resource available Springer New York LLC Date A point or period of time associated with an event in the lifecycle of the resource 2014-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/978-3-319-08105-2__31" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/978-3-319-08105-2__31</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-84910636558&amp;doi=10.1007%2F978-3-319-08105-2__31&amp;partnerID=40&amp;md5=5e12cd7351d662eccd20dd372d118879" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-84910636558&amp;doi=10.1007%2f978-3-319-08105-2__31&amp;partnerID=40&amp;md5=5e12cd7351d662eccd20dd372d118879</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 21941009; ISBN: 978-331908104-5 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Conference paper Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Francis K.J., Christ University, Bangalore, 560060, Karnataka, India; Jose I., Christ University, Bangalore, 560060, Karnataka, India