Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions
anticancer mechanisms; apoptosis; glycoalkaloids; Solanaceae; ?-Solanine
Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements in diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success in yielding effective treatments. This review focuses on ?-solanine, a glycoalkaloid primarily derived from potato tubers and nightshade family plants, recognized for its diverse biological activities, including anti-allergic, antipyretic, anti-inflammatory, anti-diabetic, and antibiotic properties. Recently, ?-solanine has gained attention as a potential anticancer agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web of Science, Scopus, the American Chemical Society, Google Scholar, Springer Link, Wiley, and various commercial websites, this review consolidates two decades of research on ?-solanine's anticancer effects and mechanisms against nine different cancers, highlighting its role in modulating various signaling pathways. It also discusses ?-solanine's potential as a lead compound in cancer therapy. The abundant availability of potato peel, often discarded as waste or sold cheaply, is suggested as a sustainable source for large-scale ?-solanine extraction. The study concludes that ?-solanine holds promise as a standalone or adjunctive cancer treatment. However, further research is necessary to optimize this lead compound and mitigate its toxicity through various strategies. 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
Nandi S.; Sikder R.; Nag A.; Khatua S.; Sen S.; Chakraborty N.; Naskar A.; Zhakipbekov K.; Acharya K.; Habtemariam S.; ArslanAte??ahin D.; Goloshvili T.; AhmedAldahish A.; Sharifi-Rad J.; Calina D.
Food Science and Nutrition, Vol-12, No. 10, pp. 7088-7107.
All Open Access; Green Open Access; Hybrid Gold Open Access
https://doi.org/10.1002/fsn3.4221 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85202883746&doi=10.1002%2ffsn3.4221&partnerID=40&md5=80d4618f510a22cd628ac2a5fc4f0aff
Nandi S., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Sikder R., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Nag A., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, India; Khatua S., Department of Botany, Faculty of Science, University of Allahabad, Uttar Pradesh, Prayagraj, India; Sen S., Department of Botany, Fakir Chand College, Kolkata, India; Chakraborty N., Department of Botany, Scottish Church College, Kolkata, India; Naskar A., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Zhakipbekov K., Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan; Acharya K., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Habtemariam S., Pharmacognosy Research & Herbal Analysis Services UK, Kent, United Kingdom; ArslanAte??ahin D., Department of Plant and Animal Production, Baskil Vocational School, F?rat University, Elaz?g, Turkey; Goloshvili T., Department of Plant Physiology and Genetic Resources, Institute of Botany, Ilia State University, Tbilisi, Georgia; AhmedAldahish A., Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia; Sharifi-Rad J., Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, South Korea; Calina D., Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania