Will the antioxidant supplements impact the mitigation of oxidative stress in Parkinsons disease?
- Title
- Will the antioxidant supplements impact the mitigation of oxidative stress in Parkinsons disease?
- Creator
- Anil Kumar D.; Balamuralikrishnan B.; Bharathi K.; Pushparaj K.; Pappuswamy M.; Meyyazhagan A.; Sangeetha T.; Kaviya M.; Vijaya Anand A.
- Description
- Parkinsons disease is a frequent neurodegenerative condition marked by both non-motor and motor symptoms. It is brought on by the selective depletion of dopamine neurons from the substantia nigra region of the midbrain. Numerous variables, including lifestyle, environment, age, smoking, and underlying medical disorders, affect the occurrence of Parkinsons disease. The free radicals created by oxidative stress have an impact on the morphology and function of neuronal cells and are a factor in many neurodegenerative disorders, including Parkinsons and Alzheimers, disorder. Although the pathophysiological mechanism causing neuronal degeneration is still unknown, oxidative stress plays a critical role in the pathogenesis of idiopathic Parkinsons disease. It also has an association with numerous proteins, including ?-synuclein, amyloid, DJ-1 protein and several signalling pathways like extracellular regulated protein kinases. Reactive oxygen species also contribute to complex Is mitochondrial respiratory activity. The naturally occurring antioxidants are the phenols, anthocyanins, carotenoids, flavonoids, vitamins, and lignans. These antioxidants retain the reactive oxygen species generation and plays a role in several biological effects. As a result, natural plant antioxidants may have an impact on Parkinsons disease and offer an alternative therapy that minimises oxidative stress and slows down the evolution of the disease. 2024 Visagaa Publishing House.
- Source
- Natural Resources for Human Health, Vol-4, No. 4, pp. 415-426.
- Date
- 2024-01-01
- Publisher
- Visagaa Publishing House
- Subject
- Antioxidants; Food supplements; Natural compounds; Neurodegenerative disorders; Oxidative stress
- Coverage
- Anil Kumar D., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Balamuralikrishnan B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, South Korea; Bharathi K., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Pushparaj K., Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, India; Pappuswamy M., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560 029, India; Meyyazhagan A., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560 029, India; Sangeetha T., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Kaviya M., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Vijaya Anand A., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India
- Rights
- All Open Access; Hybrid Gold Open Access
- Relation
- ISSN: 25831194
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Anil Kumar D.; Balamuralikrishnan B.; Bharathi K.; Pushparaj K.; Pappuswamy M.; Meyyazhagan A.; Sangeetha T.; Kaviya M.; Vijaya Anand A., “Will the antioxidant supplements impact the mitigation of oxidative stress in Parkinsons disease?,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/21271.