Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Amyotrophic Lateral Sclerosis: Insights and New Prospects in Disease Pathophysiology, Biomarkers and Therapies Subject The topic of the resource amyotrophic lateral sclerosis; diagnosis; neuroinflammation; pathology; therapies Description An account of the resource Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disorder marked by the gradual loss of motor neurons, leading to significant disability and eventual death. Despite ongoing research, there are still limited treatment options, underscoring the need for a deeper understanding of the diseases complex mechanisms and the identification of new therapeutic targets. This review provides a thorough examination of ALS, covering its epidemiology, pathology, and clinical features. It investigates the key molecular mechanisms, such as protein aggregation, neuroinflammation, oxidative stress, and excitotoxicity that contribute to motor neuron degeneration. The role of biomarkers is highlighted for their importance in early diagnosis and disease monitoring. Additionally, the review explores emerging therapeutic approaches, including inhibitors of protein aggregation, neuroinflammation modulators, antioxidant therapies, gene therapy, and stem cell-based treatments. The advantages and challenges of these strategies are discussed, with an emphasis on the potential for precision medicine to tailor treatments to individual patient needs. Overall, this review aims to provide a comprehensive overview of the current state of ALS research and suggest future directions for developing effective therapies. 2024 by the authors. Creator An entity primarily responsible for making the resource Al-Khayri J.M.; Ravindran M.; Banadka A.; Vandana C.D.; Priya K.; Nagella P.; Kukkemane K. Source A related resource from which the described resource is derived Pharmaceuticals, Vol-17, No. 10 Publisher An entity responsible for making the resource available Multidisciplinary Digital Publishing Institute (MDPI) Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.3390/ph17101391" target="_blank" rel="noreferrer noopener">https://doi.org/10.3390/ph17101391</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85207648670&amp;doi=10.3390%2Fph17101391&amp;partnerID=40&amp;md5=3cc971028850c6a78e095fc813a793bc" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85207648670&amp;doi=10.3390%2fph17101391&amp;partnerID=40&amp;md5=3cc971028850c6a78e095fc813a793bc</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 14248247 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Al-Khayri J.M., Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia; Ravindran M., Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed-to-be-University), Bangalore, 560027, India; Banadka A., Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed-to-be-University), Bangalore, 560027, India; Vandana C.D., Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed-to-be-University), Bangalore, 560027, India; Priya K., Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed-to-be-University), Bangalore, 560027, India; Nagella P., Department of Life Sciences, School of Sciences, Christ University, Bengaluru, 560029, India; Kukkemane K., Department of Life Sciences, School of Sciences, Christ University, Bengaluru, 560029, India