The unique risk factor profile of triple-negative breast cancer: a comprehensive meta-analysis
- Title
- The unique risk factor profile of triple-negative breast cancer: a comprehensive meta-analysis
- Creator
- Kumar N.; Ehsan S.; Banerjee S.; Perez C.F.; Lhuilier I.; Neuner J.; Friebel-Klingner T.; Fayanju O.M.; Nair B.; Niinuma S.A.; Nampoothiri S.; McCarthy A.M.
- Description
- Background: Triple-negative breast cancer (TNBC) has a poor prognosis compared with other breast cancer subtypes. This systematic review and meta-analysis examines whether known risk factors for breast cancer are also associated with TNBC in adult women. Methods: EMBASE, Medline, SCOPUS, and gray literature were queried with no limit on the date or language of publication. The exposures of interest included parity, breastfeeding, duration of breastfeeding, age at menarche, age at first live birth, oral contraceptive (OC) use, duration of OC use, use of menopausal hormone therapy (MHT), family history, body mass index (BMI), alcohol use, smoking, and breast density. The main outcome of interest was TNBC. Study quality was determined using the Newcastle-Ottawa scale for case control studies and cohort studies. We estimated weighted odds ratios from random effects models to study the exposureoutcome associations. Protocol was registered under the number: PROSPERO 2021 CRD42021254594. Results: Thirty-three studies were included. Family history, longer duration of OC use, and higher breast density were significantly associated with increased risk for TNBC, whereas later age at menarche, later age at first birth, and breastfeeding were protective against TNBC. Parity, MHT, alcohol, smoking, and BMI were not significantly associated with TNBC overall, but higher parity was associated with higher risk among Black women. Conclusion: Our findings highlight that TNBC has a distinct risk factor profile compared with overall breast cancer. This can be the foundational work in identification of actionable TNBC risk factors to improve prevention and early detection of these poor prognosis breast tumors. The Author(s) 2024.
- Source
- Journal of the National Cancer Institute, Vol-116, No. 8, pp. 1210-1219.
- Date
- 2024-01-01
- Publisher
- Oxford University Press
- Coverage
- Kumar N., Department of Medicine, Royal College of Surgeons in Ireland - Bahrain, Busaiteen, Bahrain; Ehsan S., Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Banerjee S., Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Perez C.F., Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Lhuilier I., Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Neuner J., Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Friebel-Klingner T., Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; Fayanju O.M., Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Nair B., Department of Medicine, Royal College of Surgeons in Ireland - Bahrain, Busaiteen, Bahrain; Niinuma S.A., Department of Medicine, Royal College of Surgeons in Ireland - Bahrain, Busaiteen, Bahrain; Nampoothiri S., Science Department, Christ University, KA, Bangalore, India; McCarthy A.M., Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Rights
- All Open Access; Hybrid Gold Open Access
- Relation
- ISSN: 278874; PubMed ID: 38445713; CODEN: JNCIA
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Kumar N.; Ehsan S.; Banerjee S.; Perez C.F.; Lhuilier I.; Neuner J.; Friebel-Klingner T.; Fayanju O.M.; Nair B.; Niinuma S.A.; Nampoothiri S.; McCarthy A.M., “The unique risk factor profile of triple-negative breast cancer: a comprehensive meta-analysis,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/21291.