Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Role of the Gut Microbiota in Neurodegenerative Diseases Subject The topic of the resource Bacteroidetes; brain; disorders; Firmicutes; gut; nerves; neurodegeneration; probiotics Description An account of the resource The human gut has a rich and dynamic microbial population that plays an important role in many physiological activities. This review explores the complex interaction between the gut microbiota and human health, with an emphasis on its effect on neurodegenerative illnesses. The makeup of the gut microbiome and its impact on brain function through the gutbrain axis is highlighted. Dysbiosis, characterized by changes in the gut microbiotas composition, has been linked to the development of neurodegenerative diseases such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. A Bidirectional communication between the stomach and the brain takes place via a variety of channels, including neurotransmitters and metabolites generated by gut bacteria. We investigate the processes through which dysbiosis causes neuroinflammation, oxidative stress, and neuronal damage, which drive disease development. Potential therapeutic approaches that focus on the gut microbiota, such as antibiotics, probiotics, prebiotics, and fecal microbiota transplantation, are reviewed, with promising preclinical and clinical findings. Overall, this study emphasizes the relevance of gut microbiota to neurodegenerative illnesses, as well as the need to understand and target the gut-brain axis for future treatment options. 2024 by the authors. Creator An entity primarily responsible for making the resource Philip Mani A.; Balasubramanian B.; Mali L.A.; Joseph K.S.; Meyyazhagan A.; Pappuswamy M.; Joseph B.V. Source A related resource from which the described resource is derived Microbiology Research, Vol-15, No. 2, pp. 489-507. Publisher An entity responsible for making the resource available Multidisciplinary Digital Publishing Institute (MDPI) Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.3390/microbiolres15020033" target="_blank" rel="noreferrer noopener">https://doi.org/10.3390/microbiolres15020033</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195643634&amp;doi=10.3390%2Fmicrobiolres15020033&amp;partnerID=40&amp;md5=6dac0f42834c3e3fed2bb25eab3b4e09" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195643634&amp;doi=10.3390%2fmicrobiolres15020033&amp;partnerID=40&amp;md5=6dac0f42834c3e3fed2bb25eab3b4e09</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 20367473; LS; 2023-2024;Vol-1; 1051-1069 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Philip Mani A., Department of Life Sciences, Christ University, Bengaluru, 560029, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Mali L.A., Department of Life Sciences, Christ University, Bengaluru, 560029, India; Joseph K.S., Department of Life Sciences, Christ University, Bengaluru, 560029, India; Meyyazhagan A., Department of Life Sciences, Christ University, Bengaluru, 560029, India; Pappuswamy M., Department of Life Sciences, Christ University, Bengaluru, 560029, India; Joseph B.V., Department of Life Sciences, Christ University, Bengaluru, 560029, India