Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Anticancer activity and other biomedical properties of ?-sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches Subject The topic of the resource anticancer activity; biomedical properties; pharmacology; phytochemistry; translational research; ?-sitosterol Description An account of the resource Sterols, including ?-sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of ?-sitosterol and its potential applications is essential for scholarly pursuits and utilization purposes. ?-sitosterol shares similar chemical characteristics with cholesterol and exhibits several pharmacological activities without major toxicity. This study aims to bridge the gap between phytochemistry and current pharmacological evidence of ?-sitosterol, focusing on its anticancer activity and other biomedical properties. The goal is to provide a comprehensive understanding of ?-sitosterol's potential for future translational approaches. A thorough examination of the literature was conducted to gather relevant information on the biological properties of ?-sitosterol, particularly its anticancer therapeutic potential. Various databases were searched, including PubMed/MedLine, Scopus, Google Scholar, and Web of Science using appropriate keywords. Studies investigating the effects of ?-sitosterol on different types of cancer were analyzed, focusing on mechanisms of action, pharmacological screening, and chemosensitizing properties. Modern pharmacological screening studies have revealed the potential anticancer therapeutic properties of ?-sitosterol against various types of cancer, including leukemia, lung, stomach, breast, colon, ovarian, and prostate cancer. ?-sitosterol has demonstrated chemosensitizing effects on cancer cells, interfering with multiple cell signaling pathways involved in proliferation, cell cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, and inflammation. Structural derivatives of ?-sitosterol have also shown anti-cancer effects. However, research in the field of drug delivery and the detailed mode of action of ?-sitosterol-mediated anticancer activities remains limited. ?-sitosterol, as a non-toxic compound with significant pharmacological potential, exhibits promising anticancer effects against various cancer types. Despite being relatively less potent than conventional cancer chemotherapeutics, ?-sitosterol holds potential as a safe and effective nutraceutical against cancer. Further comprehensive studies are recommended to explore the biological properties of ?-sitosterol, including its mode of action, and develop novel formulations for its potential use in cancer treatment. This review provides a foundation for future investigations and highlights the need for further research on ?-sitosterol as a potent superfood in combating cancer. 2023 John Wiley &amp; Sons Ltd. Creator An entity primarily responsible for making the resource Nandi S.; Nag A.; Khatua S.; Sen S.; Chakraborty N.; Naskar A.; Acharya K.; Calina D.; Sharifi-Rad J. Source A related resource from which the described resource is derived Phytotherapy Research, Vol-38, No. 2, pp. 592-619. Publisher An entity responsible for making the resource available John Wiley and Sons Ltd Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/ptr.8061" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/ptr.8061</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85176134576&amp;doi=10.1002%2Fptr.8061&amp;partnerID=40&amp;md5=ef8e53b239347dbcee615dfa8a63f881" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85176134576&amp;doi=10.1002%2fptr.8061&amp;partnerID=40&amp;md5=ef8e53b239347dbcee615dfa8a63f881</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 0951418X; PubMed ID: 37929761; CODEN: PHYRE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nandi S., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Nag A., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Khatua S., Department of Botany, Faculty of Science, University of Allahabad, Prayagraj, India; Sen S., Department of Botany, Fakir Chand College, Kolkata, India; Chakraborty N., Department of Botany, Scottish Church College, Kolkata, India; Naskar A., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Acharya K., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Calina D., Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania; Sharifi-Rad J., Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador