Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Impact of nanoparticles on immune cells and their potential applications in cancer immunotherapy Subject The topic of the resource Antigen presentation; Dendritic cells; Macrophages; Nanotechnology; T lymphocytes Description An account of the resource Nanoparticles represent a heterogeneous collection of materials, whether natural or synthetic, with dimensions aligning in the nanoscale. Because of their intense manifestation with the immune system, they can be harvested for numerous bio-medical and biotechnological advancements mainly in cancer treatment. This review article aims to scrutinize various types of nanoparticles that interact differently with immune cells like macrophages, dendritic cells, T lymphocytes, and natural killer (NK) cells. It also underscores the importance of knowing how nanoparticles influence immune cell functions, such as the production of cytokines and the presentation of antigens which are crucial for effective cancer immunotherapy. Hence overviews of bio-molecular mechanisms are provided. Nanoparticles can improve antigen presentation, boost T-cell responses, and overcome the immunosuppressive tumor environment. The regulatory mechanisms, signaling pathways, and nanoparticle characteristics are also presented for a comprehensive understanding. We review the nanotechnology platform options and challenges in nanoparticles-based immunotherapy, from an immunotherapy perspective including precise targeting, immune modulation, and potential toxicity, as well as personalized approaches based on individual patient and tumor characteristics. The development of emerging multifunctional nanoparticles and theranostic nanoparticles will provide new solutions for the precision and efficiency of cancer therapies in next-generation practice. Copyright 2024 The Authors. Creator An entity primarily responsible for making the resource Nair J.B.; Joseph A.M.; Sanoop P.; Joseph M.M. Source A related resource from which the described resource is derived Biocell, Vol-48, No. 11, pp. 1579-1602. Publisher An entity responsible for making the resource available Tech Science Press Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.32604/biocell.2024.054879" target="_blank" rel="noreferrer noopener">https://doi.org/10.32604/biocell.2024.054879</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85209541724&amp;doi=10.32604%2Fbiocell.2024.054879&amp;partnerID=40&amp;md5=d6d23215f101b56023d1218d51faf92b" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85209541724&amp;doi=10.32604%2fbiocell.2024.054879&amp;partnerID=40&amp;md5=d6d23215f101b56023d1218d51faf92b</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 3279545; CODEN: BOCEE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nair J.B., Leibniz Institute of Photonic Technology, Albert-Einstein-Stra 9, Jena, 07745, Germany, Serah Zines LLP, Sreeragam, Naduvannor P.O., Kerala, Kozhikkode, 673614, India; Joseph A.M., Department of Chemistry, Newman College, Kerala, Thodupuzha, 685585, India; Sanoop P., Department of Chemistry, Madanapalle Institute of Technology &amp; Science (MITS), Madanapalle, Andhra Pradesh, Chittoor, 517325, India; Joseph M.M., Department of Life Sciences, CHRIST University, Karnataka, Bengaluru, 560029, India