Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Understanding the Role of Antimicrobial Peptides in Neutrophil Extracellular Traps Promoting Autoimmune Disorders Subject The topic of the resource antimicrobial peptides; autoimmune disorders; cathelicidins; cytokines; defensins; neutrophil Description An account of the resource AMPs are small oligopeptides acting as integral elements of the innate immune system and are of tremendous potential in the medical field owing to their antimicrobial and immunomodulatory activities. They offer a multitude of immunomodulatory properties such as immune cell differentiation, inflammatory responses, cytokine production, and chemoattraction. Aberrancy in neutrophil or epithelial cell-producing AMPs leads to inflammation culminating in various autoimmune responses. In this review, we have tried to explore the role of prominent mammalian AMPsdefensins and cathelicidins, as immune regulators with special emphasis on their role in neutrophil extracellular traps which promotes autoimmune disorders. When complexed with self-DNA or self-RNA, AMPs act as autoantigens which activate plasmacytoid dendritic cells and myeloid dendritic cells leading to the production of interferons and cytokines. These trigger a series of self-directed inflammatory reactions, leading to the emergence of diverse autoimmune disorders. Since AMPs show both anti- and pro-inflammatory abilities in different ADs, there is a dire need for a complete understanding of their role before developing AMP-based therapy for autoimmune disorders. 2023 by the authors. Creator An entity primarily responsible for making the resource Biswas S.; Sarojini S.; Jayaram S.; Philip I.; Umesh M.; Mascarenhas R.; Pappuswamy M.; Balasubramanian B.; Arokiyaraj S. Source A related resource from which the described resource is derived Life, Vol-13, No. 6 Publisher An entity responsible for making the resource available MDPI Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.3390/life13061307" target="_blank" rel="noreferrer noopener">https://doi.org/10.3390/life13061307</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85163758647&amp;doi=10.3390%2Flife13061307&amp;partnerID=40&amp;md5=0e9348eb63472ec53eaa93bff87beab4" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85163758647&amp;doi=10.3390%2flife13061307&amp;partnerID=40&amp;md5=0e9348eb63472ec53eaa93bff87beab4</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 20751729 | LS; 2023-2024; Vol-2; 0678-0698 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biswas S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Sarojini S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Jayaram S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Philip I., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Umesh M., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Mascarenhas R., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Pappuswamy M., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Arokiyaraj S., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea