Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SARS-CoV-2 Footprints in the Placenta: What We Know after Three Years of the Pandemic Subject The topic of the resource COVID-19; entry factors; obstetric outcomes; perinatal outcomes; placental pathology; SARS-CoV-2; vertical transmission Description An account of the resource As the COVID-19 pandemic continues into its third year, there is accumulating evidence on the consequences of maternal infection. Emerging data indicate increased obstetrics risks, including maternal complications, preterm births, impaired intrauterine fetal growth, hypertensive disorders, stillbirth, gestational diabetes, and a risk of developmental defects in neonates. Overall, controversial concerns still exist regarding the potential for vertical transmission. Histopathological examination of the placenta can represent a useful instrument for investigation and can contribute significant information regarding the possible immunohistopathological mechanisms involved in developing unfavorable perinatal outcomes. Based on current evidence, SARS-CoV-2 infection can affect placental tissue by inducing several specific changes. The level of placental involvement is considered one of the determining factors for unfavorable outcomes during pregnancy due to inflammation and vascular injuries contributing to complex cascade immunological and biological events; however, available evidence does not indicate a strong and absolute correlation between maternal infection, placental lesions, and obstetric outcomes. As existing studies are still limited, we further explore the placenta at three different levels, using histology, immunohistochemistry, and molecular genetics to understand the epidemiological and virological changes observed in the ongoing pandemic. 2023 by the authors. Creator An entity primarily responsible for making the resource Tosto V.; Meyyazhagan A.; Alqasem M.; Tsibizova V.; Di Renzo G.C. Source A related resource from which the described resource is derived Journal of Personalized Medicine, Vol-13, No. 4 Publisher An entity responsible for making the resource available MDPI Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.3390/jpm13040699" target="_blank" rel="noreferrer noopener">https://doi.org/10.3390/jpm13040699</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85154026664&amp;doi=10.3390%2Fjpm13040699&amp;partnerID=40&amp;md5=a16559a5654dbc4bd3056d2ffd80f9b1" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85154026664&amp;doi=10.3390%2fjpm13040699&amp;partnerID=40&amp;md5=a16559a5654dbc4bd3056d2ffd80f9b1</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 20754426 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Tosto V., Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, 06121, Italy; Meyyazhagan A., Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, 06121, Italy, Perinatology Research Branch, Wayne State University, Detroit, 48202, MI, United States, Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Alqasem M., Department of Obstetrics and Gynecology, Faculty of Medicine, Mutah University, Al-Karak, 61710, Jordan; Tsibizova V., PREIS International School, Firenze, 50122, Italy; Di Renzo G.C., Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, 06121, Italy, PREIS International School, Firenze, 50122, Italy, Department of Obstetrics and Gynecology, IM Sechenov First State University, 19c1, Moscow, 119991, Russian Federation, Almazov National Medical Research Centre, St Petersburg, 197341, Russian Federation