Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Stilbenes, a Versatile Class of Natural Metabolites for InflammationAn Overview Subject The topic of the resource inflammation; plant secondary metabolites; resveratrol; stilbenes; viniferins; Vitis vinifera Description An account of the resource Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes, peanuts, rhubarb, berries, etc., to defend themselves under stressful conditions. They are now exploited in medicine for their antioxidant, anti-proliferative and anti-inflammatory properties. Inflammation is the immune systems response to invading bacteria, toxic chemicals or even nutrient-deprived conditions. It is characterized by the release of cytokines which can wreak havoc on healthy tissues, worsening the disease condition. Stilbenes modulate NF-?B, MAPK and JAK/STAT pathways, and reduce the transcription of inflammatory factors which result in maintenance of homeostatic conditions. Resveratrol, the most studied stilbene, lowers the Michaelis constant of SIRT1, and occupies the substrate binding pocket. Gigantol interferes with the complement system. Besides these, oxyresveratrol, pterostilbene, polydatin, viniferins, etc., are front runners as drug candidates due to their diverse effects from different functional groups that affect bioavailability and molecular interactions. However, they each have different thresholds for toxicity to various cells of the human body, and thus a careful review of their properties must be conducted. In animal models of autoinflammatory diseases, the mode of application of stilbenes is important to their absorption and curative effects, as seen with topical and microemulsion gel methods. This review covers the diversity seen among stilbenes in the plant kingdom and their mechanism of action on the different inflammatory pathways. In detail, macrophages contribution to inflamed conditions in the liver, the cardiac, connective and neural tissues, in the nephrons, intestine, lungs and in myriad other body cells is explored, along with detailed explanation on how stilbenes alleviate the symptoms specific to body site. A section on the bioavailability of stilbenes is included for understanding the limitations of the natural compounds as directly used drugs due to their rapid metabolism. Current delivery mechanisms include sulphonamides, or using specially designed synthetic drugs. It is hoped that further research may be fueled by this comprehensive work that makes a compelling argument for the exploitation of these compounds in medicine. 2023 by the authors. Creator An entity primarily responsible for making the resource Al-Khayri J.M.; Mascarenhas R.; Harish H.M.; Gowda Y.; Lakshmaiah V.V.; Nagella P.; Al-Mssallem M.Q.; Alessa F.M.; Almaghasla M.I.; Rezk A.A.-S. Source A related resource from which the described resource is derived Molecules, Vol-28, No. 9 Publisher An entity responsible for making the resource available MDPI Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.3390/molecules28093786" target="_blank" rel="noreferrer noopener">https://doi.org/10.3390/molecules28093786</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159271506&amp;doi=10.3390%2Fmolecules28093786&amp;partnerID=40&amp;md5=83cac4fc92747d4ed5959ba63d848796" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159271506&amp;doi=10.3390%2fmolecules28093786&amp;partnerID=40&amp;md5=83cac4fc92747d4ed5959ba63d848796</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 14203049; PubMed ID: 37175197; CODEN: MOLEF Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Al-Khayri J.M., Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Mascarenhas R., Department of Life Sciences, CHRIST (Deemed to Be University), Bangalore, 560029, India; Harish H.M., Department of Life Sciences, CHRIST (Deemed to Be University), Bangalore, 560029, India; Gowda Y., Department of Life Sciences, CHRIST (Deemed to Be University), Bangalore, 560029, India; Lakshmaiah V.V., Department of Life Sciences, CHRIST (Deemed to Be University), Bangalore, 560029, India; Nagella P., Department of Life Sciences, CHRIST (Deemed to Be University), Bangalore, 560029, India; Al-Mssallem M.Q., Department of Food Science and Nutrition, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Alessa F.M., Department of Food Science and Nutrition, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Almaghasla M.I., Department of Arid Land Agriculture, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia, Plant Pests, and Diseases Unit, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Rezk A.A.-S., Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia, Department of Virus and Phytoplasma, Plant Pathology Institute, Agricultural Research Center, Giza, 12619, Egypt