Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Exploring the anti-inflammatory activities, mechanism of action and prospective drug delivery systems of tocotrienol to target neurodegenerative diseases Subject The topic of the resource anti-inflammatory; drug delivery; nanotechnology; neurodegenerative diseases; Tocotrienols; vitamin E Description An account of the resource A major cause of death in the elderly worldwide is attributed to neurodegenerative diseases, such as AD (Alzheimers disease), PD (Parkinsons disease), ALS (Amyotrophic lateral sclerosis), FRDA (Friedreichs ataxia), VaD (Vascular dementia) etc. These can be caused due to multiple factors such as genetic, physiological problems like stroke or tumor, or even external causes like viruses, toxins, or chemicals. T3s (tocotrienols) exhibit various bioactive properties where it acts as an antioxidant, anti-inflammatory, anti-tumorigenic, and cholesterol lowering agent. Since T3 interferes with and influences several anti-inflammatory mechanisms, it aids in combating inflammatory responses that lead to disease progression. T3s are found to have a profound neuroprotective ability, however, due to their poor oral bioavailability, their full potential could not be exploited. Hence there is a need to explore other drug delivery techniques, especially focusing on aspects of nanotechnology. In this review paper we explore the anti-inflammatory mechanisms of T3 to apply it in the treatment of neurodegenerative diseases and also discusses the possibilities of nano methods of administering tocotrienols to target neurodegenerative diseases. Copyright: 2023 Mathew AM et al. Creator An entity primarily responsible for making the resource Mathew A.M.; Bhuvanendran S.; Nair R.S.; K Radhakrishnan A. Source A related resource from which the described resource is derived F1000Research, Vol-12 Publisher An entity responsible for making the resource available F1000 Research Ltd Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.12688/f1000research.131863.1" target="_blank" rel="noreferrer noopener">https://doi.org/10.12688/f1000research.131863.1</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85204511732&amp;doi=10.12688%2Ff1000research.131863.1&amp;partnerID=40&amp;md5=247565c62fbcbd786643008834cb7d28" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85204511732&amp;doi=10.12688%2ff1000research.131863.1&amp;partnerID=40&amp;md5=247565c62fbcbd786643008834cb7d28</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 20461402; PubMed ID: 39291146 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Mathew A.M., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Bhuvanendran S., Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor, 47500, Malaysia; Nair R.S., School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, 47500, Malaysia; K Radhakrishnan A., Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor, 47500, Malaysia