Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cadmium toxicity in medicinal plants: An overview of the tolerance strategies, biotechnological and omics approaches to alleviate metal stress Subject The topic of the resource cadmium; CRISPR- Cas 9; medicinal plants; plant secondary metabolites; reactive oxygen species; transporters Description An account of the resource Medicinal plants, an important source of herbal medicine, are gaining more demand with the growing human needs in recent times. However, these medicinal plants have been recognized as one of the possible sources of heavy metal toxicity in humans as these medicinal plants are exposed to cadmium-rich soil and water because of extensive industrial and agricultural operations. Cadmium (Cd) is an extremely hazardous metal that has a deleterious impact on plant development and productivity. These plants uptake Cd by symplastic, apoplastic, or via specialized transporters such as HMA, MTPs, NRAMP, ZIP, and ZRT-IRT-like proteins. Cd exerts its effect by producing reactive oxygen species (ROS) and interfere with a range of metabolic and physiological pathways. Studies have shown that it has detrimental effects on various plant growth stages like germination, vegetative and reproductive stages by analyzing the anatomical, morphological and biochemical changes (changes in photosynthetic machinery and membrane permeability). Also, plants respond to Cd toxicity by using various enzymatic and non-enzymatic antioxidant systems. Furthermore, the ROS generated due to the heavy metal stress alters the genes that are actively involved in signal transduction. Thus, the biosynthetic pathway of the important secondary metabolite is altered thereby affecting the synthesis of secondary metabolites either by enhancing or suppressing the metabolite production. The present review discusses the abundance of Cd and its incorporation, accumulation and translocation by plants, phytotoxic implications, and morphological, physiological, biochemical and molecular responses of medicinal plants to Cd toxicity. It explains the Cd detoxification mechanisms exhibited by the medicinal plants and further discusses the omics and biotechnological strategies such as genetic engineering and gene editing CRISPR- Cas 9 approach to ameliorate the Cd stress. Copyright 2023 Al-Khayri, Banadka, Rashmi, Nagella, Alessa and Almaghasla. Creator An entity primarily responsible for making the resource Al-Khayri J.M.; Banadka A.; Rashmi R.; Nagella P.; Alessa F.M.; Almaghasla M.I. Source A related resource from which the described resource is derived Frontiers in Plant Science, Vol-13 Publisher An entity responsible for making the resource available Frontiers Media S.A. Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.3389/fpls.2022.1047410" target="_blank" rel="noreferrer noopener">https://doi.org/10.3389/fpls.2022.1047410</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147182552&amp;doi=10.3389%2Ffpls.2022.1047410&amp;partnerID=40&amp;md5=87cd043536ef2b9ac94ce676c4de0cb1" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147182552&amp;doi=10.3389%2ffpls.2022.1047410&amp;partnerID=40&amp;md5=87cd043536ef2b9ac94ce676c4de0cb1</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 1664462X Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Al-Khayri J.M., Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, Saudi Arabia; Banadka A., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, India; Rashmi R., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, India; Nagella P., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, India; Alessa F.M., Department of Food Science and Nutrition, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, Saudi Arabia; Almaghasla M.I., Department of Arid Land Agriculture, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, Saudi Arabia, Plant Pests, and Diseases Unit, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, Saudi Arabia