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                <text>Reviews</text>
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    <name>Review</name>
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              <text>Review on microbially synthesized nanoparticles: a potent biocontrol agent against Aedes species of mosquito</text>
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              <text>Aedes aegypti; Dengue; Insecticides; Nanoparticles</text>
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              <text>Aedes aegypti is a principal vector of dengue, chikungunya and Zika illnesses worldwide. Because effective vaccinations or medications for the prevention and/or treatment for these illnesses are not available, vector management has been embraced as the primary method of reducing their transmission. The strategy that is often used for controlling Aedes populations is chemical insecticides; however, despite their efficiency, extensive usage of these pesticides has resulted in high operating costs, the establishment of resistant populations and undesirable non-target impacts. Therefore, the use of nanoparticles derived from multiple synthesis processes as new insecticides has recently attracted the interest of researchers. This study provides an overview of the current understanding concerning the method of action of nanoparticles against mosquitoes. Metal nanoparticles strongly influence antioxidant and detoxifying enzymes in insects, causing oxidative stress and cell death. These nanoparticles similarly inhibited acetylcholinesterase activity. Metal-based nanoparticles can potentially bind to S and P units in proteins and nucleic acids respectively resulting in decreased membrane permeability, organelle and enzyme denaturation which leads to cell death. Furthermore, they upregulate and downregulate critical insect genes, lower protein synthesis and gonadotrophin release, resulting in developmental and reproductive failure. This review critically examines insect nanotoxicology research trends and highlights the ecotoxicological effects of practical usage of nanoparticles as insecticides.  2022 World Research Association. All rights reserved.</text>
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              <text>Jincy G.A.; Sejal D.; Saher T.; Gopishankar T.; Paari K.A.</text>
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              <text>Research Journal of Biotechnology, Vol-17, No. 12, pp. 171-189.</text>
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              <text>World Research Association</text>
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              <text>2022-01-01</text>
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              <text>&lt;a href="https://doi.org/10.25303/1712rjbt1710189" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.25303/1712rjbt1710189&lt;/a&gt;
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              <text>Restricted Access</text>
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              <text>ISSN: 9736263</text>
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              <text>Online</text>
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              <text>Review</text>
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              <text>Jincy G.A., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Sejal D., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Saher T., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Gopishankar T., Centre for Chemical Biology and Therapeutics, Institute of Stem Cell Science and Regenerative Medicine, Bangalore, India; Paari K.A., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India</text>
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