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              <text>Therapeutic potential of marine macrolides: An overview from 1990 to 2022</text>
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              <text>Macrolides; Marine pharmacology; Structure activity relationships; Therapeutic drug targets</text>
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              <text>The sea is a vast ecosystem that has remained primarily unexploited and untapped, resulting in numerous organisms. Consequently, marine organisms have piqued the interest of scientists as an abundant source of natural resources with unique structural features and fascinating biological activities. Marine macrolide is a top-class natural product with a heavily oxygenated polyene backbone containing macrocyclic lactone. In the last few decades, significant efforts have been made to isolate and characterize macrolides' chemical and biological properties. Numerous macrolides are extracted from different marine organisms such as marine microorganisms, sponges, zooplankton, molluscs, cnidarians, red algae, tunicates, and bryozoans. Notably, the prominent macrolide sources are fungi, dinoflagellates, and sponges. Marine macrolides have several bioactive characteristics such as antimicrobial (antibacterial, antifungal, antimalarial, antiviral), anti-inflammatory, antidiabetic, cytotoxic, and neuroprotective activities. In brief, marine organisms are plentiful in naturally occurring macrolides, which can become the source of efficient and effective therapeutics for many diseases. This current review summarizes these exciting and promising novel marine macrolides in biological activities and possible therapeutic applications.  2022 The Authors</text>
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          <name>Creator</name>
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              <text>Das R.; Rauf A.; Mitra S.; Emran T.B.; Hossain M.J.; Khan Z.; Naz S.; Ahmad B.; Meyyazhagan A.; Pushparaj K.; Wan C.C.; Balasubramanian B.; Rengasamy K.R.; Simal-Gandara J.</text>
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              <text>Chemico-Biological Interactions, Vol-365</text>
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              <text>Elsevier Ireland Ltd</text>
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              <text>2022-01-01</text>
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              <text>&lt;a href="https://doi.org/10.1016/j.cbi.2022.110072" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.1016/j.cbi.2022.110072&lt;/a&gt;
&lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135791829&amp;amp;doi=10.1016%2Fj.cbi.2022.110072&amp;amp;partnerID=40&amp;amp;md5=0085af8fb33bf878187104946ab046fe" target="_blank" rel="noreferrer noopener"&gt;https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135791829&amp;amp;doi=10.1016%2fj.cbi.2022.110072&amp;amp;partnerID=40&amp;amp;md5=0085af8fb33bf878187104946ab046fe&lt;/a&gt;</text>
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              <text>All Open Access; Green Open Access; Hybrid Gold Open Access</text>
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              <text>ISSN: 92797; PubMed ID: 35952775; CODEN: CBINA</text>
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              <text>Online</text>
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              <text>Das R., Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh; Rauf A., Department of Chemistry, University of Swabi, Swabi, 94640, Pakistan; Mitra S., Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh; Emran T.B., Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh, Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh; Hossain M.J., Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka, 1205, Bangladesh; Khan Z., Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh; Naz S., Department of Biotechnology, Bacha Khan University, Charsadda, KPK, Pakistan; Ahmad B., Department of Biotechnology, Bacha Khan University, Charsadda, KPK, Pakistan; Meyyazhagan A., Department of Life Science, CHRIST (Deemed to be University), Bengaluru, 560076, Karnataka, India; Pushparaj K., Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, 641 043, Tamil Nadu, India; Wan C.C., Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruit &amp;amp;Vegetables, Collaborative Innovation Center of Postharvest Key Technology and Quality Safety of Fruit &amp;amp; Vegetables, College of Agronomy, Jiangxi Agricultural University Nanchang, 330045, Jiangxi, China; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Rengasamy K.R., Centre for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 600077, India; Simal-Gandara J., Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E-32004 Ourense, Spain</text>
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