Current scenario of Gastric cancer (GC): A systematic review

Title

Current scenario of Gastric cancer (GC): A systematic review

Creator

Manikantan P.; Anushka S.; Arun M.; Balamuralikrishnan B.; Anand A.V.

Description

Gastric cancer (GC) is amongst the most difficult cancers to treat and, hence, has to be studied from the roots to be properly analysed. The disease starts as precancerous lesions which have to be observed. This includes dysplasia, atrophic gastritis and intestinal metaplasia. This is effective for detecting the prognosis of GC so that it can be resolved in early stages. This is dependent on a variety of risk factors which include blood type, gender, age, geography, gene polymorphisms, acid secretion, pernicious anemia, oxidative damage, previous gastric surgery, etc. Probably the most important, however, is infection by H. Pylori. With respect to virulence factors and host factors, both are significant players in the development of several cases of malignancies. Other genetic factors and lifestyle choices including alcohol use, tobacco usage and obesity, will also be analysed. There are also several genetic conditions that cause high risk of development into a malignancy including Menetrier s disease, hereditary diffuse GC, Lynch syndrome, Peutz-Jeghers syndrome, Li Fraumani syndrome etc. Several diagnostic procedures such as lab tests, physical examinations and biopsy are used. The current review analysed the factors which are involved in the prognosis and causative agents in the development of GC. This is to better understand how GC can be diagnosed and confirmed. This may include molecular testing, including genes, which can be of high risk followed by modern treatment methods discussing surgery, chemotherapy, immunotherapy and radiotherapy. Chemotherapy includes discussion of several drugs and how they target the malignancy in question. By understanding the disease in detail, through causes, prognosis, detection and treatment, we can go one step closer to find the cure for GC. 2022 World Research Association. All rights reserved.

Source

Research Journal of Biotechnology, Vol-17, No. 9, pp. 134-144.

Date

2022-01-01

Publisher

World Research Association

Subject

Digestive system disorder; Food habits; Gastric Cancer.; Genetic factor

Coverage

Manikantan P., Department of Life Sciences, CHRIST (Deemed to Be) University, Bangalore, 560029, India; Anushka S., Department of Life Sciences, CHRIST (Deemed to Be) University, Bangalore, 560029, India; Arun M., Department of Life Sciences, CHRIST (Deemed to Be) University, Bangalore, 560029, India; Balamuralikrishnan B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, South Korea; Anand A.V., Department of Human Molecular Genetics, Bharathiar University, Coimbatore, 641046, India

Rights

Restricted Access

Relation

ISSN: 9736263

Format

Online

Language

English

Type

Review

Identifier

https://doi.org/10.25303/1709rjbt1340144

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139769489&doi=10.25303%2f1709rjbt1340144&partnerID=40&md5=462c328b78cb7887cf8400762fbddc1a