Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Puzzle of Hereditary Spastic Paraplegia: From Epidemiology to Treatment Subject The topic of the resource clinical manifestations; drugs; genes; hereditary spastic paraplegia; pathways; therapies Description An account of the resource Inherited neurodegenerative pathology characterized by lower muscle tone and increasing spasticity in the lower limbs is termed hereditary spastic paraplegia (HSP). HSP is associated with changes in about 80 genes and their products involved in various biochemical pathways, such as lipid droplet formation, endoplasmic reticulum shaping, axon transport, endosome trafficking, and mitochondrial function. With the inheritance patterns of autosomal dominant, autosomal recessive, X-linked recessive, and mitochondrial inheritance, HSP is prevalent around the globe at a rate of 15 cases in every 100,000 individuals. Recent technology and medical interventions somewhat aid in recognizing and managing the malaise. However, HSP still lacks an appropriate and adequate therapeutic approach. Current therapies are based on the clinical manifestations observed in the patients, for example, smoothing the relaxant spastic muscle and physiotherapies. The limited clinical trial studies contribute to the absence of specific pharmaceuticals for HSPs. Our current work briefly explains the causative genes, epidemiology, underlying mechanism, and the management approach undertaken to date. We have also mentioned the latest approved drugs to summarise the available knowledge on therapeutic strategies for HSP. 2022 by the authors. Creator An entity primarily responsible for making the resource Meyyazhagan A.; Kuchi Bhotla H.; Pappuswamy M.; Orlacchio A. Source A related resource from which the described resource is derived International Journal of Molecular Sciences, Vol-23, No. 14 Publisher An entity responsible for making the resource available MDPI Date A point or period of time associated with an event in the lifecycle of the resource 2022-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.3390/ijms23147665" target="_blank" rel="noreferrer noopener">https://doi.org/10.3390/ijms23147665</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135132487&amp;doi=10.3390%2Fijms23147665&amp;partnerID=40&amp;md5=022b1783c1fd4de7ba56856185a678dc" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135132487&amp;doi=10.3390%2fijms23147665&amp;partnerID=40&amp;md5=022b1783c1fd4de7ba56856185a678dc</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 16616596; PubMed ID: 35887006 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Meyyazhagan A., Dipartimento di Medicina e Chirurgia, Universitdi Perugia, Perugia, 06132, Italy; Kuchi Bhotla H., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Pappuswamy M., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Orlacchio A., Dipartimento di Medicina e Chirurgia, Universitdi Perugia, Perugia, 06132, Italy, Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello (CERC), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, 00179, Italy