Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis Subject The topic of the resource Biotransformation; Detoxification; Dietary prophylaxis; Ochratoxin; Toxicokinetics Description An account of the resource Ochratoxin A (OTA) is a toxic metabolite produced by Aspergillus and Penicillium fungi commonly found in raw plant sources and other feeds. This review comprises an extensive evaluation of the origin and proprieties of OTA, toxicokinetics, biotransformation, and toxicodynamics of ochratoxins. In in vitro and in vivo studies, the compatibility of OTA with oxidative stress is observed through the production of free radicals, resulting in genotoxicity and carcinogenicity. The OTA leads to nephrotoxicity as the chief target organ is the kidney. Other OTA excretion and absorption rates are observed, and the routes of elimination include faeces, urine, and breast milk. The alternations in the Phe moiety of OTA are the precursor for the amino acid alternation, bringing about Phe-hydroxylase and Phe-tRNA synthase, resulting in the complete dysfunction of cellular metabolism. Biodetoxification using specific microorganisms decreased the DNA damage, lipid peroxidation, and cytotoxicity. This review addressed the ability of antioxidants and the dietary components as prophylactic measures to encounter toxicity and demonstrated their capability to counteract the chronic exposure through supplementation as feed additives. 2022 Elsevier Ltd Creator An entity primarily responsible for making the resource Liu W.-C.; Pushparaj K.; Meyyazhagan A.; Arumugam V.A.; Pappuswamy M.; Bhotla H.K.; Baskaran R.; Issara U.; Balasubramanian B.; Mousavi Khaneghah A. Source A related resource from which the described resource is derived Toxicon, Vol-213, pp. 59-75. Publisher An entity responsible for making the resource available Elsevier Ltd Date A point or period of time associated with an event in the lifecycle of the resource 2022-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.toxicon.2022.04.012" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.toxicon.2022.04.012</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129290299&amp;doi=10.1016%2Fj.toxicon.2022.04.012&amp;partnerID=40&amp;md5=ff8e2421597dafd652765e0b6d37f796" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129290299&amp;doi=10.1016%2fj.toxicon.2022.04.012&amp;partnerID=40&amp;md5=ff8e2421597dafd652765e0b6d37f796</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 410101; PubMed ID: 35452686; CODEN: TOXIA Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Liu W.-C., Department of Animal Science, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, 524088, China; Pushparaj K., Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, 641 043, India; Meyyazhagan A., Department of Life Science, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560076, India; Arumugam V.A., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, 641 046, India; Pappuswamy M., Department of Life Science, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560076, India; Bhotla H.K., Department of Animal Science, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, 524088, China; Baskaran R., Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan; Issara U., Division of Food Science and Technology Management, Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi, Pathum Thani, 12110, Thailand; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Mousavi Khaneghah A., Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas (UNICAMP), S Paulo, Campinas, Brazil