Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Flavonoids as Potential Anti-Inflammatory Molecules: A Review Subject The topic of the resource anti-inflammation; flavonoids; natural products; phenolic compounds; phytochemicals Description An account of the resource Hydroxylated polyphenols, also called flavonoids, are richly present in vegetables, fruits, cereals, nuts, herbs, seeds, stems, and flowers of numerous plants. They possess numerous medicinal properties such as antioxidant, anti-cancer, anti-microbial, neuroprotective, and anti-inflammation. Studies show that flavonoids activate antioxidant pathways that render an anti-inflammatory effect. They inhibit the secretions of enzymes such as lysozymes and ?-glucuronidase and inhibit the secretion of arachidonic acid, which reduces inflammatory reactions. Flavonoids such as quercetin, genistein, apigenin, kaempferol, and epigallocatechin 3-gallate modulate the expression and activation of a cytokine such as interleukin-1beta (IL-1?), Tumor necrosis factor-alpha (TNF-?), interleukin-6 (IL-6), and interleukin-8 (IL-8); regulate the gene expression of many pro-inflammatory molecules such s nuclear factor kappa-light chain enhancer of activated B cells (NF-?B), activator protein-1 (AP-1), intercellular adhesion molecule-1 (ICAM), vascular cell adhesion molecule-1 (VCAM), and E-selectins; and also inhibits inducible nitric oxide (NO) synthase, cyclooxygenase-2, and lipoxygenase, which are pro-inflammatory enzymes. Understanding the anti-inflammatory action of flavonoids provides better treatment options, including coronavirus disease 2019 (COVID-19)-induced inflammation, inflammatory bowel disease, obstructive pulmonary disorder, arthritis, Alzheimers disease, cardiovascular disease, atherosclerosis, and cancer. This review highlights the sources, biochemical activities, and role of flavonoids in enhancing human health. 2022 by the authors. Licensee MDPI, Basel, Switzerland. Creator An entity primarily responsible for making the resource Al-Khayri J.M.; Sahana G.R.; Nagella P.; Joseph B.V.; Alessa F.M.; Al-Mssallem M.Q. Source A related resource from which the described resource is derived Molecules, Vol-27, No. 9 Publisher An entity responsible for making the resource available MDPI Date A point or period of time associated with an event in the lifecycle of the resource 2022-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.3390/molecules27092901" target="_blank" rel="noreferrer noopener">https://doi.org/10.3390/molecules27092901</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130039738&amp;doi=10.3390%2Fmolecules27092901&amp;partnerID=40&amp;md5=027774fdf6c2c4c741cd8b31d3323f6c" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130039738&amp;doi=10.3390%2fmolecules27092901&amp;partnerID=40&amp;md5=027774fdf6c2c4c741cd8b31d3323f6c</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 14203049; PubMed ID: 35566252; CODEN: MOLEF Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Al-Khayri J.M., Department of Plant Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Sahana G.R., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, India; Nagella P., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, India; Joseph B.V., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, India; Alessa F.M., Department of Food Science and Nutrition, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Al-Mssallem M.Q., Department of Food Science and Nutrition, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia