Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from Artemisia annua L. Subject The topic of the resource Agrobacterium rhizogenes; Artemisia annua; Artemisinin; bioreactor; cell suspension culture; elicitation Description An account of the resource Artemisinin is an anti-malarial sesquiterpene lactone derived from Artemisia annua L. (Aster-aceae family). One of the most widely used modes of treatment for malaria is an artemisinin-based combination therapy. Artemisinin and its associated compounds have a variety of pharmacological qualities that have helped achieve economic prominence in recent years. So far, research on the biosynthesis of this bioactive metabolite has revealed that it is produced in glandular trichomes and that the genes responsible for its production must be overexpressed in order to meet demand. Using biotechnological applications such as tissue culture, genetic engineering, and bioreactor-based approaches would aid in the upregulation of artemisinin yield, which is needed for the future. The current review focuses on the tissue culture aspects of propagation of A. annua and production of artemisinin from A. annua L. cell and organ cultures. The review also focuses on elicitation strategies in cell and organ cultures, as well as artemisinin biosynthesis and metabolic engineering of biosynthetic genes in Artemisia and plant model systems. 2022 by the authors. Licensee MDPI, Basel, Switzerland. Creator An entity primarily responsible for making the resource Al-Khayri J.M.; Sudheer W.N.; Lakshmaiah V.V.; Mukherjee E.; Nizam A.; Thiruvengadam M.; Nagella P.; Alessa F.M.; Al-Mssallem M.Q.; Rezk A.A.; Shehata W.F.; Attimarad M. Source A related resource from which the described resource is derived Molecules, Vol-27, No. 9 Publisher An entity responsible for making the resource available MDPI Date A point or period of time associated with an event in the lifecycle of the resource 2022-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.3390/molecules27093040" target="_blank" rel="noreferrer noopener">https://doi.org/10.3390/molecules27093040</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130023077&amp;doi=10.3390%2Fmolecules27093040&amp;partnerID=40&amp;md5=487409d3bdbca310330b6f42faed392b" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130023077&amp;doi=10.3390%2fmolecules27093040&amp;partnerID=40&amp;md5=487409d3bdbca310330b6f42faed392b</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 14203049; PubMed ID: 35566390; CODEN: MOLEF Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Al-Khayri J.M., Department of Plant Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Sudheer W.N., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India; Lakshmaiah V.V., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India; Mukherjee E., Amity Institute of Biotechnology, Amity University, Noida, 201313, India; Nizam A., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Thiruvengadam M., Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, 05029, South Korea; Nagella P., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India; Alessa F.M., Department of Food Science and Nutrition, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Al-Mssallem M.Q., Department of Food Science and Nutrition, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Rezk A.A., Department of Plant Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Shehata W.F., Department of Plant Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia; Attimarad M., Department of Pharmacology, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, 31982, Saudi Arabia