ItemReview

COVID-19 in pregnant women and children: Insights on clinical manifestations, complexities, and pathogenesis

Title
COVID-19 in pregnant women and children: Insights on clinical manifestations, complexities, and pathogenesis
Creator
Meyyazhagan A.; Pushparaj K.; Balasubramanian B.; Kuchi Bhotla H.; Pappusamy M.; Arumugam V.A.; Easwaran M.; Pottail L.; Mani P.; Tsibizova V.; Di Renzo G.C.
Description
Pregnancy changes the body's immune system to counteract the spectrum of infections, including COVID-19, which can pose complications. Pregnant women are less likely to contract COVID-19 infections than the general public. However, pregnant women are at slightly increased risk of becoming severely unwell if they do catch COVID-19, and congenital conditions in pregnant women may worsen the state of infection and lead to critical stages and even mortality. The possibility of vertical transmission has been reported in only a few cases of COVID-19; however, it was not noted in cases of SARS and MERS. Vaccination coverage in pregnant women remains a challenge. Children are the next suspected and vulnerable population to acquire infection after the first and second waves. Children are disproportionately infected compared with older populations, but the severity of infection is less compared to adults. This review highlights the complexities of COVID-19 in pregnant women and the underlying reasons why children tend to be comparatively less severely affected. Ethnicity, nutrition, lifestyle, and therapeutics influence the severity of infection in children. Low expression of angiotensin-converting enzyme 2 receptors, indigenous virus competence, and maternal immunity is the first-line defense for children against COVID-19. Habituating herbal medicines from childhood may help support a robust and defensive immune system to counteract novel antigens and encourage healthy generations. 2021 International Federation of Gynecology and Obstetrics
Source
International Journal of Gynecology and Obstetrics, Vol-156, No. 2, pp. 216-224.
Date
2022-01-01
Publisher
John Wiley and Sons Ltd
Coverage
Meyyazhagan A., Department of Obstetrics and Gynecology and Centre for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy, Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Pushparaj K., Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, South Korea; Kuchi Bhotla H., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Pappusamy M., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Arumugam V.A., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Easwaran M., Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi, India; Pottail L., Department of Chemistry, School of Physical and Computational Sciences, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, India; Mani P., Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, India; Tsibizova V., Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, Saint Petersburg, Russian Federation; Di Renzo G.C., Department of Obstetrics and Gynecology and Centre for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy
Rights
All Open Access; Green Open Access
Relation
ISSN: 207292; PubMed ID: 34735717; CODEN: IJGOA
Format
Online
Language
English
Type
Review

Collection

Reviews

Citation

Meyyazhagan A.; Pushparaj K.; Balasubramanian B.; Kuchi Bhotla H.; Pappusamy M.; Arumugam V.A.; Easwaran M.; Pottail L.; Mani P.; Tsibizova V.; Di Renzo G.C., “COVID-19 in pregnant women and children: Insights on clinical manifestations, complexities, and pathogenesis,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/21552.

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