GalNAc-siRNA conjugates: Prospective tools on the frontier of anti-viral therapeutics
- Title
- GalNAc-siRNA conjugates: Prospective tools on the frontier of anti-viral therapeutics
- Creator
- Thangamani L.; Balasubramanian B.; Easwaran M.; Natarajan J.; Pushparaj K.; Meyyazhagan A.; Piramanayagam S.
- Description
- The growing use of short-interfering RNA (siRNA)-based therapeutics for viral diseases reflects the most recent innovations in anti-viral vaccines and drugs. These drugs play crucial roles in the fight against many hitherto incurable diseases, the causes, pathophysiologies, and molecular processes of which remain unknown. Targeted liver drug delivery systems are in clinical trials. The receptor-mediated endocytosis approach involving the abundant asialoglycoprotein receptors (ASGPRs) on the surfaces of liver cells show great promise. We here review N-acetylgalactosamine (GalNAc)-siRNA conjugates that treat viral diseases such as hepatitis B infection, but we also mention that novel, native conjugate-based, targeted siRNA anti-viral drugs may also cure several life-threatening diseases such as hemorrhagic cystitis, multifocal leukoencephalopathy, and severe acute respiratory syndrome caused by coronaviruses and human herpes virus. 2021 Elsevier Ltd
- Source
- Pharmacological Research, Vol-173
- Date
- 2021-01-01
- Publisher
- Academic Press
- Subject
- GalNac conjugate; Hepatitis B; Hepatocytes; SiRNA; Virus
- Coverage
- Thangamani L., Computational Biology Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Easwaran M., International Centre for Genetic Engineering and Biotechnology, 110067, New Delhi, India; Natarajan J., Data Mining and Text Mining Laboratory, Department of Bioinformatics, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India; Pushparaj K., Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, 641043, Tamil Nadu, India; Meyyazhagan A., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, Karnataka, India; Piramanayagam S., Computational Biology Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India
- Rights
- All Open Access; Green Open Access
- Relation
- ISSN: 10436618; PubMed ID: 34474100; CODEN: PHMRE
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Thangamani L.; Balasubramanian B.; Easwaran M.; Natarajan J.; Pushparaj K.; Meyyazhagan A.; Piramanayagam S., “GalNAc-siRNA conjugates: Prospective tools on the frontier of anti-viral therapeutics,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/21577.