A Journey toward the Syntheses of ?-Amino-?-hydroxybutyric Acid (GABOB) and Carnitine

Title

A Journey toward the Syntheses of ?-Amino-?-hydroxybutyric Acid (GABOB) and Carnitine

Creator

Tadiparthi K.; Anand P.

Description

In this review, we discuss the synthetic approaches to ?-amino-?-hydroxybutyric acid (GABOB) and carnitine from 1980 to date. The unique structure and biological importance of these molecules have created much interest in various synthetic approaches over the last four decades by organic chemists from across the world. Most of the syntheses are asymmetric methods that involved chiral pool, enantioselective synthesis, enzyme resolution, or a chiral auxiliary as a source of chirality, and the biological significance of the molecules was also discussed. The compiled synthetic methods may fill the existence gap, simplify the complexity involved in the synthesis, and allow the best synthetic route to be found by comparison of all the methods. However, this review also will be useful to prepare similar kind of scaffolds present in various complex natural products. 2021 American Chemical Society

Source

Organic Process Research and Development, Vol-25, No. 9, pp. 2008-2019.

Date

2021-01-01

Publisher

American Chemical Society

Subject

ascorbic acid; carnitine; GABOB; lipase resolution; mannitol; Sharpless dihydroxylation; total synthesis

Coverage

Tadiparthi K., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560026, India; Anand P., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560026, India

Rights

Restricted Access

Relation

ISSN: 10836160; CODEN: OPRDF

Format

Online

Language

English

Type

Review

Identifier

https://doi.org/10.1021/acs.oprd.1c00027

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114356150&doi=10.1021%2facs.oprd.1c00027&partnerID=40&md5=53cf592d9b72348c9acb064d976c35ee