Review - Electrochemical Strategies for Selective Fluorination of Organic Compounds
The conventional methods for carrying out fluorination of organic compounds are typically conducted using a pre-modified starting material, usually expensive and toxic reagents. In this regard, electrochemical fluorination has been recognized as a sustainable and scalable strategy. Electrofluorination has proven to be an environmentally benign, highly effective, and versatile platform for the synthesis of selective organofluorine compounds under mild conditions. This review provides an overview on the use of anodic electrochemical methods for vicinal difluorination, iodofluorination, fluoroalkynylation, fluorodecarboxylation, fluoro desulfurization, radiofluorination, and synthesis of fluorinated heterocycles. Modern advances in the field of electrochemical fluorination, such as ionic liquids mediated electrochemical fluorination, triethylammonium halides, mixed non-aqueous solvents, alkali-metal fluoride, and split-bipolar electrodes in the field of electrochemical fluorination are also discussed. 2021 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.
Thadathil D.A.; Varghese A.; Radhakrishnan K.V.
Journal of the Electrochemical Society, Vol-168, No. 7
https://doi.org/10.1149/1945-7111/ac148f https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111774698&doi=10.1149%2f1945-7111%2fac148f&partnerID=40&md5=8743f32c22886d1e3cc1a52ed18efea1
Thadathil D.A., Department of Chemistry, CHRIST (Deemed to Be University), Bengaluru, Karnataka, 560029, India; Varghese A., Department of Chemistry, CHRIST (Deemed to Be University), Bengaluru, Karnataka, 560029, India; Radhakrishnan K.V., Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, 695019, India