Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reviews Review Faculty Publications- Reviews Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Advances in Carbon-Element Bond Construction under Chan-Lam Cross-Coupling Conditions: A Second Decade Subject The topic of the resource C-N bond formation; C-O bond formation; Chan-Lam coupling; copper mediated; copper-catalyzed; N-arylation Description An account of the resource Copper-mediated carbon-heteroatom bond-forming reactions involving a wide range of substrates have been in the spotlight for many organic chemists. This review highlights developments between 2010 and 2019 in both stoichiometric and catalytic copper-mediated reactions, and also examples of nickel-mediated reactions, under modified Chan-Lam cross-coupling conditions using various nucleophiles; examples include chemo- and regioselective N-arylations or O-arylations. The utilization of various nucleophiles as coupling partners together with reaction optimization (including the choice of copper source, ligands, base, and other additives), limitations, scope, and mechanisms are examined; these have benefitted the development of efficient and milder methods. The synthesis of medicinally valuable or pharmaceutically important nitrogen heterocycles, including isotope-labeled compounds, is also included. Chan-Lam coupling reaction can now form twelve different C-element bonds, making it one of the most diverse and mild reactions known in organic chemistry. 1 Introduction 2 Construction of C-N and C-O Bonds 2.1 C-N Bond Formation 2.1.1 Original Discovery via Stoichiometric Copper-Mediated C-N Bond Formation 2.1.2 Copper-Catalyzed C-N Bond Formation 2.1.3 Coupling with Azides, Sulfoximines, and Sulfonediimines as Nitrogen Nucleophiles 2.1.4 Coupling with N, N -Dialkylhydroxylamines 2.1.5 Enolate Coupling with sp 3-Carbon Nucleophiles 2.1.6 Nickel-Catalyzed Chan-Lam Coupling 2.1.7 Coupling with Amino Acids 2.1.8 Coupling with Alkylboron Reagents 2.1.9 Coupling with Electron-Deficient Heteroarylamines 2.1.10 Selective C-N Bond Formation for the Synthesis of Heterocycle-Containing Compounds 2.1.11 Using Sulfonato-imino Copper(II) Complexes 2.2 C-O Bond Formation 2.2.1 Coupling with (Hetero)arylboron Reagents 2.2.2 Coupling with Alkyl- and Alkenylboron Reagents 3 C-Element (Element = S, P, C, F, Cl, Br, I, Se, Te, At) Bond Forma tion under Modified Chan-Lam Conditions 4 Conclusions. 2021 Georg Thieme Verlag. All rights reserved. Creator An entity primarily responsible for making the resource Vijayan A.; Rao D.N.; Radhakrishnan K.V.; Lam P.Y.S.; Das P. Source A related resource from which the described resource is derived Synthesis (Germany), Vol-53, No. 5, pp. 805-847. Publisher An entity responsible for making the resource available Georg Thieme Verlag Date A point or period of time associated with an event in the lifecycle of the resource 2021-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1055/s-0040-1705971" target="_blank" rel="noreferrer noopener">https://doi.org/10.1055/s-0040-1705971</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098077178&amp;doi=10.1055%2Fs-0040-1705971&amp;partnerID=40&amp;md5=3da7612f4973a5947129485a34dda359" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098077178&amp;doi=10.1055%2fs-0040-1705971&amp;partnerID=40&amp;md5=3da7612f4973a5947129485a34dda359</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 397881; CODEN: SYNTB Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Review Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Vijayan A., Department of Chemistry, CHRIST, Deemed to Be University, Hosur road, Bengaluru, 560029, India, CSIR, National Institute for Interdisciplinary Science and Technology, Industrial Estate PO, Thiruvananthapuram, 695019, India; Rao D.N., Department of Chemistry, Indian Institute of Technology (ISM), Dhanbad, 826004, India; Radhakrishnan K.V., CSIR, National Institute for Interdisciplinary Science and Technology, Industrial Estate PO, Thiruvananthapuram, 695019, India; Lam P.Y.S., Baruch S. Blumberg Institute, Doylestown, 18902, PA, United States; Das P., Department of Chemistry, Indian Institute of Technology (ISM), Dhanbad, 826004, India