Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era
- Title
- Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era
- Creator
- Chandra Mohana N.; Yashavantha Rao H.C.; Rakshith D.; Mithun P.R.; Nuthan B.R.; Satish S.
- Description
- The need for a new antibiotic pipeline to confront threat imposed by resistant pathogens has become a major global concern for human health. To confront the challenge there is a need for discovery and development of new class of antibiotics. Nature which is considered treasure trove, there is re-emerged interest in exploring untapped microbial to yield novel molecules, due to their wide array of negative effects associated with synthetic drugs. Natural product researchers have developed many new techniques over the past few years for developing diverse compounds of biopotential. Taking edge in the advancement of genomics, genetic engineering, in silico drug design, surface modification, scaffolds, pharmacophores and target-based approach is necessary. These techniques have been economically sustainable and also proven efficient in natural product discovery. This review will focus on recent advances in diverse discipline approach from integrated Bioinformatics predictions, genetic engineering and medicinal chemistry for the synthesis of natural products vital for the discovery of novel antibiotics having potential application. 2018
- Source
- Journal of Genetic Engineering and Biotechnology, Vol-16, No. 1, pp. 1-8.
- Date
- 2018-01-01
- Publisher
- Academy of Scientific Research and Technology
- Subject
- Combinatorial synthesis and antibiotics; Genome mining; Genome shuffling; Metabolomics
- Coverage
- Chandra Mohana N., Microbial Drugs Laboratory, Department of Studies in Microbiology, Manasagangotri, University of Mysore, Mysore, 570006, Karnataka, India; Yashavantha Rao H.C., Microbial Drugs Laboratory, Department of Studies in Microbiology, Manasagangotri, University of Mysore, Mysore, 570006, Karnataka, India; Rakshith D., Microbial Drugs Laboratory, Department of Studies in Microbiology, Manasagangotri, University of Mysore, Mysore, 570006, Karnataka, India; Mithun P.R., Department of Life Sciences, Christ University, Bengaluru, 560029, Karnataka, India; Nuthan B.R., Microbial Drugs Laboratory, Department of Studies in Microbiology, Manasagangotri, University of Mysore, Mysore, 570006, Karnataka, India; Satish S., Microbial Drugs Laboratory, Department of Studies in Microbiology, Manasagangotri, University of Mysore, Mysore, 570006, Karnataka, India
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 1687157X
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Chandra Mohana N.; Yashavantha Rao H.C.; Rakshith D.; Mithun P.R.; Nuthan B.R.; Satish S., “Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 22, 2025, https://archives.christuniversity.in/items/show/21656.