Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Waliaveettil, Felicia Aswathy; Edathottiyil Issac, Anila Title A name given to the resource Aloe Vera Protein Encapsulated Platinum Nanoparticles for Pain and Inflammation Therapy Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Advanced Therapeutics;Volume;9;Issue;1;Article No.;e00477; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/adtp.202500477" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/adtp.202500477</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105028220659?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105028220659?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Waliaveettil F.A., Department of Physics and Electronics, CHRIST University, Karnataka, Bengaluru, India; Edathottiyil Issac A., Department of Physics and Electronics, CHRIST University, Karnataka, Bengaluru, India Description An account of the resource Platinum nanoparticles (Pt NPs) possess unique redox activity, chemical stability, and enzyme-mimetic properties, making them promising candidates for anti-inflammatory and analgesic therapies; however, protein-based green encapsulation strategies for such applications remain largely unexplored. In this study, we report the biochemically assisted synthesis of Aloe vera protein-encapsulated platinum nanoparticles (APPt NPs) using sodium borohydride as the reducing agent and freshly extracted Aloe vera proteins as both stabilizing and capping agents. The formation of Pt NPs was confirmed by a characteristic colour change and validated through physicochemical characterization. X-ray diffraction revealed a face-centred cubic crystalline structure, UVvisible spectroscopy showed absorption in the 220280 nm range due to surface plasmon resonance, and FTIR analysis confirmed the presence of protein functional groups on the nanoparticle surface. APPt NPs demonstrated significant biological efficacy. In vitro assays showed inhibition of protein denaturation (IC50 = 44.52 g/mL) and strong free-radical scavenging activity (IC50 = 10.39 g/mL). In vivo studies revealed ?60% analgesic efficacy at 50 mg kg?1 in the hot-plate model and ?50% inhibition of carrageenan-induced paw edema after 4 h, outperforming the standard drug. These results collectively highlight APPt NPs as a biocompatible, redox-active nanotherapeutic candidate for managing pain and inflammation. 2026 Wiley-VCH GmbH. Subject The topic of the resource Aloe vera protein; anti-inflammatory activity; carrageenan-induced paw edema model; DPPH assay; platinum nanoparticles Publisher An entity responsible for making the resource available John Wiley and Sons Inc Relation A related resource ISSN: 23663987; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online