ItemArticle

Biocidal Activity of Barium and Iron-Co-Doped Titanium Dioxide Nanocomposites, Synthesized by Psidium guajava-Mediated Precipitation Method

Title
Biocidal Activity of Barium and Iron-Co-Doped Titanium Dioxide Nanocomposites, Synthesized by Psidium guajava-Mediated Precipitation Method
Creator
Goyal, Saumya; Ballal, Suhas; Punia, Ankit; Sharma, Deeplata; Nagpal, Manish; Pathak, Jaivik; Thangavelu, Indumathi; Tadepalli, Srinivas
Description
The emergence of drug-resistant microorganisms and the need for effective anticancer agents necessitate the development of novel nanomaterials with enhanced biomedical performance. This study aims to synthesize barium and iron dual-doped titanium dioxide (TiBaFeO NC) using a green precipitation method with Psidium guajava leaf extract, targeting improved antimicrobial and anticancer efficacy. The synthesized nanocomposite was characterized by various analytical techniques. XRD confirmed the crystalline anatase phase of TiO2 and TiBaFeO NC, with average crystallite sizes of 40 and 37nm, respectively, suitable for biomedical applications. UV-Vis analysis showed a decrease in bandgap from 3.79eV for TiO2 to 3.67eV for TiBaFeO NC, indicating enhanced reactive oxygen species (ROS) generation potential. PL spectra exhibited green emissions at 520nm for TiO2 and 523nm for TiBaFeO NC, reflecting a higher oxygen vacancy defect density in the doped nanocomposite. Biological evaluations demonstrated that TiBaFeO NC exhibited superior antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, Bacillus megaterium), Gram-negative bacteria (Shigella dysenteriae, Escherichia coli, Proteus vulgaris), and fungi (Candida albicans). Furthermore, TiBaFeO NC showed enhanced anticancer activity against human breast cancer cells (MDA-MB-231) with an IC50 of 9.8g/mL, outperforming TiO2. These results suggest that TiBaFeO NC is a promising nanocomposite for advanced biomedical applications, combining enhanced antimicrobial and anticancer properties through defect-mediated ROS generation. 2026 International Union of Biochemistry and Molecular Biology, Inc.
Source
Biotechnology and Applied Biochemistry;
Date
01-01-2026
Publisher
John Wiley and Sons Inc
Subject
antimicrobial activity and anticancer activity; barium and iron; dual-doped TiO2; nanomaterial; Psidium guajava
Coverage
Goyal S., Quantum University Research Center, Quantum University, Uttarakhand, Roorkee, India; Ballal S., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, India; Punia A., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, India; Sharma D., Department of Sciences, Vivekananda Global University, Rajasthan, Jaipur, India; Nagpal M., Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, Baddi, India; Pathak J., Department of Applied Science, PIT, Parul University, Gujarat, Vadodara, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed-to-be University), Karnataka, Bangalore, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 8854513; CODEN: BABIE
Format
online
Language
English
Type
Article

Citation

Goyal, Saumya; Ballal, Suhas; Punia, Ankit; Sharma, Deeplata; Nagpal, Manish; Pathak, Jaivik; Thangavelu, Indumathi; Tadepalli, Srinivas, “Biocidal Activity of Barium and Iron-Co-Doped Titanium Dioxide Nanocomposites, Synthesized by Psidium guajava-Mediated Precipitation Method,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/21749.

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