ItemArticle

Dual-Responsive Excited-State Intramolecular Double-Proton Transfer-Based Optical Probe for Hypochlorite and Picric Acid Detection With Applications in 3D-Printed Indicators, Biosensing, and Theranostics

Title
Dual-Responsive Excited-State Intramolecular Double-Proton Transfer-Based Optical Probe for Hypochlorite and Picric Acid Detection With Applications in 3D-Printed Indicators, Biosensing, and Theranostics
Creator
Kumar, Malavika S.; Das, Avijit Kumar; Mathias, Royston; Kumbhakar, Partha; Karan, Gouri; Choudhury, Sujata Maiti
Description
A dual-mode fluorescent probe incorporating aggregation-induced emission (AIE) activity, named 2-((E)-1-(((E)-4-(diethylamino)-2-hydroxybenzylidene)hydrazineylidene)ethyl)naphthalen-1-ol (DHN), was formulated and synthesized for the selective detection of explosive picric acid (PA) and hypochlorite (OCl?) via suppression of the excited-state intramolecular double-proton transfer (ESIDPT) mechanism. A significant fluorescence quenching of DHN at 535 nm was observed upon interaction with both PA and OCl? with the detection limits at 0.012 ?M and 2.34 ?M as well as high quenching efficiencies (Ksv) of 3.811 104 M?1 and 1.164 104 M?1, respectively. To elucidate the sensing behavior, various spectroscopic techniques were employed. Interestingly, DHN exhibited AIE behavior in high water content, showing a red-shifted emission accompanied by a visible fluorescence change from whitish green to yellow. As a novel application, DHN was incorporated into a 3D-printed polymer system, demonstrating its practical utility in detecting PA and OCl?. Further, for biological relevance, the interaction of DHN with OCl? was explored for its cytotoxicity against MCF-7 breast cancer cells and its imaging capability in physiological media. Therefore, we believe that the present work provides a promising direction for the future development of optical-based detection of hypochlorite and picric acid in liquid as well as solid phases. 2026 Wiley-VCH GmbH.
Source
ChemPhotoChem;Volume;10;Issue;4;Article No.;e202600003;
Date
01-01-2026
Publisher
John Wiley and Sons Inc
Subject
3D printing; anticancer; biosensor; excited-state intramolecular double-proton transfer; fluorescence
Coverage
Kumar M.S., Department of Chemistry, Christ University, Karnataka, Bangalore, India, Centre for Renewable Energy and Environmental Sustainability, Christ University, Karnataka, Bangalore, India; Das A.K., Department of Chemistry, Christ University, Karnataka, Bangalore, India, Centre for Renewable Energy and Environmental Sustainability, Christ University, Karnataka, Bangalore, India; Mathias R., Department of Physics and Electronics, Christ University, Karnataka, Bangalore, India; Kumbhakar P., Department of Physics and Electronics, Christ University, Karnataka, Bangalore, India; Karan G., Cancer Nanotherapeutics Laboratory, Biochemistry, Molecular Endocrinology, and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University, Midnapore, India; Choudhury S.M., Cancer Nanotherapeutics Laboratory, Biochemistry, Molecular Endocrinology, and Reproductive Physiology Division, Department of Human Physiology, Vidyasagar University, Midnapore, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 23670932;
Format
online
Language
English
Type
Article

Citation

Kumar, Malavika S.; Das, Avijit Kumar; Mathias, Royston; Kumbhakar, Partha; Karan, Gouri; Choudhury, Sujata Maiti, “Dual-Responsive Excited-State Intramolecular Double-Proton Transfer-Based Optical Probe for Hypochlorite and Picric Acid Detection With Applications in 3D-Printed Indicators, Biosensing, and Theranostics,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 17, 2026, https://archives.christuniversity.in/items/show/21765.

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