Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Borah, Nayana; Ganesan, Subbulakshmi; Singh, Manpreet; Srivastava, Nidhi; Thangavelu, Indumathi; Bhran, Ahmed A.; Tadepalli, Srinivas Title A name given to the resource Pluronic F127 and Dopamine Functionalized Fe2O3 Nanocomposites: A Multifunctional Polymer-Based Platform for Anticancer, Antibacterial, and Antioxidant Applications Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Polymers for Advanced Technologies;Volume;36;Issue;11;Article No.;e70413; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/pat.70413" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/pat.70413</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105021383076?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105021383076?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Borah N., Department of Life Sciences, School of Sciences, JAIN (Deemed-To-Be University), Karnataka, India; Ganesan S., Department of Chemistry and Biochemistry, JAIN (Deemed-To-Be University), Karnataka, Bangalore, India; Singh M., Center of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, India; Srivastava N., Maharishi School of Pharmaceutical Sciences, Maharishi University of Information Technology, Uttar Pradesh, Lucknow, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Bangalore, India; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia Description An account of the resource Cancer, bacterial infections, and oxidative stress continue to pose serious global health challenges, necessitating the development of multifunctional therapeutic agents. Iron oxide (Fe2O3) nanoparticles were selected as the core material owing to their intrinsic biocompatibility, redox activity, and established biomedical relevance. To overcome the limitations of particle aggregation and poor solubility, pluronic F127 (a biocompatible triblock copolymer) was employed as a stabilizer, while dopamine was introduced as a surface modifier to enhance functionalization, improve dispersion, and facilitate cellular uptake. The resulting Fe2O3-PF127-DOP nanocomposites were thoroughly characterized using XRD, FTIR, SEM, TEM, PL, and XPS analyses, confirming successful functionalization and enhanced stability. Antioxidant assays revealed 79.24% activity at 20 ?g/mL, comparable to Vitamin C, highlighting its antioxidant activity. Antibacterial studies against multiple pathogenic strains, including Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Shigella dysenteriae, and Vibrio cholerae, showed markedly larger inhibition zones for Fe2O3-PF127-DOP than for Fe2O3, confirming its broad-spectrum antibacterial potential. Fe2O3-PF127-DOP exhibited superior cytotoxicity against HCT-116 colon cancer cells (IC50 = 15.3 ?g/mL) compared to Fe2O3 (IC50 = 17.2 ?g/mL), attributed to improved uptake and ROS-mediated apoptosis. Importantly, cytocompatibility studies on L929 fibroblast cells revealed high cell viability of 83% and 86% for Fe2O3 and Fe2O3-PF127-DOP, respectively, demonstrating the nanocomposite's biocompatibility. Overall, this study demonstrates that strategic functionalization of Fe2O3 with pluronic F127 and dopamine yields a stable, multifunctional nanocomposite with significant anticancer, antioxidant, and antibacterial applications. 2025 John Wiley &amp; Sons Ltd. Subject The topic of the resource antibacterial activity; anticancer activity; antioxidant activity; biomedical applications; Fe₂O₃-PF127-DOP nanocomposites; HCT-116 colon cancer cells; reactive oxygen species Publisher An entity responsible for making the resource available John Wiley and Sons Ltd Relation A related resource ISSN: 10427147; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online