Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Thangavelu, Indumathi; Tadepalli, Srinivas; A. AlGhamdi, AbdulAziz; Boopathi, Thalakulam Shanmugam Title A name given to the resource Chitosan and L-histidine coated biofunctional TiO? composite with enhanced ROS-mediated antimicrobial and anticancer efficacy for biomedical applications Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Naunyn-Schmiedeberg's Archives of Pharmacology;Volume;398;Issue;12;pp.17895-17906 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s00210-025-04367-6" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s00210-025-04367-6</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105009206453?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105009206453?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; A. AlGhamdi A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India Description An account of the resource Societies continue to face the urgent challenge of developing effective, safe, and stable nanoparticles with promising biomedical applications. Herein, the present study synthesis chitosan and L-Histidine dually coated titanium dioxide (TiCSLH) nanocomposite (NC) by chemical co-precipitation method. The antimicrobial performance of TiO? nanoparticles is closely linked to their physicochemical properties, such as reduced particle size, increased bandgap, and the presence of oxygen vacancies, all of which collectively enhance reactive oxygen species (ROS) generation and inhibit microbial growth. Structural analyses using XRD and TEM confirmed that TiCSLH nanoparticles possess an anatase phase and a spherical morphology. Compared to TiO?, TiCSLH nanoparticles demonstrated significantly enhanced antimicrobial activity against MRSA, E. coli, K. pneumoniae, P. aeruginosa and C. albicans strains, as evidenced by larger zones of inhibition from 2324mm. This enhanced efficacy is attributed to their smaller particle size (~ 26 3nm), wider bandgap (3.34eV), and prominent oxygen vacancy-related emissions at 518 and 531nm, which facilitate increased ROS production, resulting in cellular membrane disruption and microbial death. Furthermore, compared to TiO2, TiCSLH exhibited notable anticancer potential against breast cancer cells, with an IC?? of 10?g/mL, while maintaining excellent biocompatibility, as evidenced by its non-toxic response toward L929 fibroblast cells, which showed 83.5% cell viability. Collectively, these findings underscore the potential of TiCSLH nanoparticles for diverse biomedical applications. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025. Subject The topic of the resource Breast cancer cell; Chitosan; L-Histidine; MRSA; TiO₂ Publisher An entity responsible for making the resource available Springer Science and Business Media Deutschland GmbH Relation A related resource ISSN: 281298; CODEN: NSAPC Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online