Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Siddhartha, Marupati; Ahlawat, Shruti; Sahu, Chandra Prabha; Krishna, Gopidesi Radha; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A. Title A name given to the resource Nickel oxide modified with sodium alginate and dopamine nanoparticles for enhanced antimicrobial, antioxidant, and anticancer activity against HepG2 cells Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Naunyn-Schmiedeberg's Archives of Pharmacology;Volume;399;Issue;2;pp.3017-3033 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s00210-025-04607-9" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s00210-025-04607-9</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105017466095?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105017466095?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Siddhartha M., Department of Chemistry, Vardhaman College of Engineering, Hyderabad, India; Ahlawat S., Department of Life Sciences, Faculty of Allied Health Sciences, SGT University, Haryana, Gurugram, India; Sahu C.P., Department of Electrical &amp; Electronics, ARKA JAIN University, Jharkhand, Jamshedpur, India; Krishna G.R., Department of Mechanical Engineering, Presidency University, Karnataka, Bengaluru, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia Description An account of the resource Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, while multidrug-resistant bacterial infections pose escalating health threats. To address these challenges, nickel oxide nanoparticles (NiO Nanoparticles) and sodium alginatedopamineNiO-SA-Dop nanoparticles (NiO-SA-Dop Nanoparticles) were synthesized and extensively characterized for multifunctional biomedical applications. X-ray diffraction revealed crystallite sizes of 40.6nm (NiO) and 29.76nm (NiO-SA-Dop). Transmission electron microscope analysis confirmed spherical morphology with reduced particle size upon modification, supporting improved surface properties. UVvisible spectroscopy showed band gap energies of 4.15eV (NiO) and 4.44eV (NiO-SA-Dop). Photoluminescence spectra indicated enhanced green emission in NiO-SA-Dop, suggesting a higher concentration of oxygen vacancies Linked to increased reactive oxygen species Generation. In functional assays, NiO-SA-Dop demonstrated superior free radical scavenging efficiency in the 2,2-diphenyl-1-picrylhydrazyl assay compared to NiO. Strong antibacterial activity was observed against Gram-negative pathogens including Pseudomonas aeruginosa, Klebsiella pneumoniae, Vibrio cholerae, Escherichia coli, and Shigella dysenteriae. Cytotoxicity assays against HepG2 cells yielded IC?? values of 11.9g/mL for NiO and 10.3g/mL for NiO-SA-Dop, underscoring the enhanced anticancer efficacy of the modified nanoparticles. Overall, NiO-SA-Dop Nanoparticles exhibit promising antibacterial, antioxidant, and anticancer activities, making them strong candidates for advanced therapeutic development. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025. Subject The topic of the resource Antibacterial activity; Cancer therapy; Cytotoxicity HepG2 cells; DPPH radical scavenging; NiO; NiO-SA-Dop; Reactive oxygen species Publisher An entity responsible for making the resource available Springer Science and Business Media Deutschland GmbH Relation A related resource ISSN: 281298; CODEN: NSAPC Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online