Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Thangavelu, Indumathi; Tadepalli, Srinivas Title A name given to the resource Chitosan coated multifunctional NiFe?O? nanocomposites as a promising candidate for biomedical applications Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Naunyn-Schmiedeberg's Archives of Pharmacology; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s00210-025-04904-3" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s00210-025-04904-3</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105028308245?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105028308245?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11432, Riyadh, Saudi Arabia Description An account of the resource Nanoparticles for biomedical applications often suffer from limited stability, low biocompatibility, and suboptimal therapeutic efficacy. To address these challenges, NiFe?O? nanoparticles were functionalized with chitosan (NiFe?O?-CS) via a co-precipitation method, aiming to enhance their structural, optical, antimicrobial, and anticancer properties. XRD analysis revealed a reduction in crystallite size from 37 to 33nm after chitosan modification, indicating controlled crystal growth and increased surface area. TEM results confirmed a corresponding decrease in particle size from 35 2.1nm to 29 1.8nm, improving surface reactivity and stability. PL spectra exhibited a red-shift in green emission peaks, suggesting increased oxygen vacancies and defect states that facilitate ROS generation. Antimicrobial assays against methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans (C.albicans) demonstrated significantly higher activity for NiFe?O?-CS nanocomposites, supported by SEM imaging that showed extensive microbial membrane disruption. Furthermore, NiFe?O?-CS exhibited enhanced anticancer activity against C6 glioma cells, with an IC?? of 35.6g/mL compared to 43.6g/mL for unmodified nanoparticles. Zebrafish embryo studies confirmed the biocompatibility of NiFe?O?-CS at appropriate doses, although dose-dependent embryotoxicity was observed. These findings highlight that chitosan functionalization of dual-metal nanoparticles improves therapeutic efficacy through increased surface interactions and ROS generation while underscoring the need for careful dose optimization. This study presents a novel strategy for designing biopolymer-coated nanocomposites that balance enhanced biomedical performance with safety considerations. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026. Subject The topic of the resource Biocompatibility; Embryotoxic; Glioma cancer; MRSA; NiFe₂O₄; Zebrafish Publisher An entity responsible for making the resource available Springer Science and Business Media Deutschland GmbH Relation A related resource ISSN: 281298; CODEN: NSAPC Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online