Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Sandilya, Manabendra; Sahu, Pratap Kumar; Pasha, Mahaboob; Bhasin, Menka; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A. Title A name given to the resource Synthesis and characterization of NiTiO?L-ornithine nanoparticles and their antibacterial, antifungal, antioxidant activities, and zebrafish biocompatibility Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Naunyn-Schmiedeberg's Archives of Pharmacology; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s00210-026-05277-x" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s00210-026-05277-x</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105035118234?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105035118234?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Sandilya M., Department of Biomedical Engineering, Faculty of Engineering and Technology, Parul Institute of Technology, Parul University, Gujarat, Vadodara, 391760, India; Sahu P.K., Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Odisha, Bhubaneswar, 751030, India; Pasha M., Department of Physics, Presidency University, Karnataka, Bengaluru, 560064, India; Bhasin M., Department of FBAS (Chemistry), Vivekananda Global University, Jaipur, 303012, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia Description An account of the resource The increasing prevalence of antimicrobial resistance and biofilm-associated infections demands multifunctional nanomaterials with improved efficacy and safety. In this study, defect-engineered nickel titanate (NiTiO?) nanoparticles functionalized with L-Ornithine (NiTiO?LO) were synthesized via a co-precipitation approach to enhance antimicrobial performance while maintaining biocompatibility. XRD analysis confirmed phase-pure rhombohedral NiTiO? with reduced crystallite size upon functionalization (31.3 2nm to 26.2 2nm). XPS and FTIR analyses verified successful LO surface coordination and modulation of oxygen vacancyrelated defect states. PL studies revealed defect-mediated green emissions (507529nm), indicating stabilized oxygen vacancies after functionalization. NiTiO?LO exhibited significantly enhanced antibacterial and antifungal activity, with inhibition zones of 17.9 0.4mm and 18.9 0.4mm, respectively. The nanoparticles also demonstrated concentration-dependent antioxidant activity, achieving ~ 63% DPPH scavenging at 100g/mL, comparable to Vitamin C (~ 65%). Importantly, zebrafish embryo assays showed no observable developmental toxicity, indicating favourable in vivo biocompatibility. These findings establish NiTiO?-LO as a defect-modulated, multifunctional nanoplatform integrating antimicrobial, antioxidant, and biocompatible properties for potential biomedical applications. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026. Subject The topic of the resource Antimicrobial activity; Antioxidant; Biocompatibility; LO; NiTiO₃ Publisher An entity responsible for making the resource available Springer Science and Business Media Deutschland GmbH Relation A related resource ISSN: 281298; CODEN: NSAPC Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online