Clitoria ternatea flower extract assisted synthesis of Pluronic F127 and l-histidine coated SrO2 as a multimodality nanocomposite for anti-cancer, anti-oxidant, and antimicrobial activities
- Title
- Clitoria ternatea flower extract assisted synthesis of Pluronic F127 and l-histidine coated SrO2 as a multimodality nanocomposite for anti-cancer, anti-oxidant, and antimicrobial activities
- Creator
- Sharma, Aakash; Ballal, Suhas; Sharma, Deeplata; Pathak, Jaivik; AlGhamdi, AbdulAziz A.; Tadepalli, Srinivas; Thangavelu, Indumathi
- Description
- Hepatocellular carcinoma (HepG2) is a highly aggressive liver cancer with poor prognosis, limited treatment options, and high mortality rates, making it a serious global health concern that demands urgent development of more effective and safer therapeutic approaches. In this context, the present study focuses on the green synthesis of SrO2 nanoparticles using Clitoria ternatea flower extract, followed by surface modification with Pluronic F127 (PF127) and L-histidine (LH), to fabricate SrO2-PF127-LH nanocomposites aimed at evaluating their potential anticancer efficacy against the HepG2 cell line. Various analytical techniques were used to characterize the nanocomposite, and then their anticancer activity against HePG2 liver cancer cells, antioxidant properties, and antimicrobial activity against the bacteria mentioned above were evaluated. XRD revealed the crystalline nature of SrO2 with atetragonal phase. FTIR spectrum confirmed the SrO stretching band at 573cm?1 for SrO2-PF127-LH nanocomposite. UVvisible analysis revealed the band gap energies of 4.13eV for SrO2 and 4.07eV forSrO2PF127LH nanocomposite. The surface defects including oxygen vacancies of SrO2-PF127-LH nanocomposite were investigated using PL analysis. The SrO2PF127LH nanocomposite exhibited excellent antibacterial and antioxidant activities when compared to SrO2 nanoparticles alone. In addition, the SrO2PF127LH nanocomposite had enhanced anticancer activity against liver cancer (HePG2) cell lines. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.
- Source
- Bioprocess and Biosystems Engineering;Volume;48;Issue;11;pp.1801-1816
- Date
- 01-01-2025
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Subject
- Antimicrobial activity; Antioxidant activity; Clitoria ternatea extract; HePG2 liver cancer; l-histidine; Pluronic F127; Reactive oxygen species (ROS); SrO? nanoparticles
- Coverage
- Sharma A., Centre of Research Impact and Outcome, Chitkara University, 140417, Punjab, Rajpura, India; Ballal S., Department of Chemistry and Biochemistry, JAIN (Deemed-to-Be University), Karnataka, Bangalore, 560069, India; Sharma D., Department of Sciences, Vivekananda Global University, Jaipur, 303012, India; Pathak J., Department of Applied Science, PIT, Parul University, Gujarat, Vadodara, 391760, India; AlGhamdi A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bangalore, 560029, India
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 16157591; CODEN: BBEIB
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Sharma, Aakash; Ballal, Suhas; Sharma, Deeplata; Pathak, Jaivik; AlGhamdi, AbdulAziz A.; Tadepalli, Srinivas; Thangavelu, Indumathi, “Clitoria ternatea flower extract assisted synthesis of Pluronic F127 and l-histidine coated SrO2 as a multimodality nanocomposite for anti-cancer, anti-oxidant, and antimicrobial activities,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21846.