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                <text>Faculty Publications</text>
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              <text>Varghese, Nikita; Thomas, Jisha Mary; John, Athira Maria; Baby Chakrapani, P.S.; Nair, Yamuna</text>
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              <text>ESIPT Active Schiff Base Fluorescent Sensor for Selective and Sensitive Detection of Co(II) Ions: Experimental, DFT Optimization Studies and Real Sample Analysis</text>
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              <text>01-01-2026</text>
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              <text>Journal of Fluorescence;Volume;36;Issue;3;pp.1973-1985</text>
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          <name>Identifier</name>
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              <text>&lt;a href="https://doi.org/10.1007/s10895-025-04679-z" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.1007/s10895-025-04679-z&lt;/a&gt; &lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.scopus.com/pages/publications/105026588655?origin=resultslist" target="_blank" rel="noreferrer noopener"&gt;https://www.scopus.com/pages/publications/105026588655?origin=resultslist&lt;/a&gt;</text>
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              <text>Varghese N., Department of Chemistry, Christ University, Bangalore, 560029, India; Thomas J.M., Department of Chemistry, Christ University, Bangalore, 560029, India; John A.M., Department of Chemistry, Christ University, Bangalore, 560029, India; Baby Chakrapani P.S., Department of Biotechnology, Cochin University of Science and Technology, Kochi, 682022, India; Nair Y., Department of Chemistry, Christ University, Bangalore, 560029, India</text>
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              <text>A novel fluorescent Schiff base chemosensor, N1,N6-bis((E)-3,5-dibromo-2-hydroxybenzylidene)adipohydrazide (DBSA), has been developed for the detection of Cobalt (II) ions. DBSA exhibits distinct fluorescence enhancement upon interacting with Co(II) ions via photoinduced electron transfer (PET). The developed sensor demonstrates a remarkable sensitivity, with the detection limits of 9.9 nM for Co(II) ions, which aligns well with the Environmental Protection Agency (EPA) regulatory thresholds for drinking water contaminants. Structural characterization by LC-MS, FTIR coupled with Jobs plot and NMR titration studies confirm the formation of DBSA-Co complex with a binding constant of 4.61 106 M? 1. The chemo sensor exhibits a quantum yield of 0.082, highlighting its potential applicability in photochemical processes. Computation studies were used to further investigate the binding interactions with Co2+ ions. The practical utility of DBSA has been validated through successful analyses in varied aqueous matrices, including tap water, lake water and recycled water. Cytotoxicity assessment via MTT assays on SH-SY5Y cells confirms excellent biocompatibility of the probe. This work presents a significant advancement in the design of efficient molecular probes for environmental monitoring, offering a robust platform for the concurrent detection of transition-metal ions in aqueous systems.  The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.</text>
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              <text>Co&lt;sup&gt;2+&lt;/sup&gt; ions; Cytotoxicity; ESIPT; Fluorescence; Real sample analysis</text>
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              <text>ISSN: 10530509; CODEN: JOFLE</text>
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              <text>Restricted Access; Hardcopy may be available in the library</text>
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              <text>online</text>
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