Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Rekha, M.M.; Ojha, Varun; Mewada, Bhavesh; Gupta, Swati; Chinnathambi, Arunachalam; Alahmadi, Tahani Awad; Arulselvan, Palanisamy; Thangavelu, Indumathi Title A name given to the resource Green Synthesis of Hydroxyapatite Nanoparticles Using Semecarpus anacardium Linn leaf Extract: Examination of Anticancer Activity and its Apoptosis Induction Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Journal of Inorganic and Organometallic Polymers and Materials;Volume;35;Issue;4;pp.3128-3142 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s10904-024-03448-y" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s10904-024-03448-y</a> <br /><br /><a href="https://www.scopus.com/pages/publications/85210490251?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/85210490251?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Rekha M.M., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, 560069, India; Ojha V., Centre for Research and Development, Chitkara University, Himachal Pradesh, 174103, India; Mewada B., Department of Mechanical Engineering, PIT, Parul University, Gujarat, Vadodara, 31760, India; Gupta S., Department of Sciences, Vivekananda Global University, Jaipur, 303012, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, PO Box - 2455, Riyadh, 11451, Saudi Arabia; Alahmadi T.A., Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, PO Box-2925, Medical City, Riyadh, 11461, Saudi Arabia; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 602105, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India Description An account of the resource Nanotechnology and biomedical sciences enable diverse molecular and cellular applications. Plant-mediated biosynthesis of nanoparticles, a green chemistry approach, offers a cost-effective, eco-friendly alternative to traditional methods. This study focuses on developing hydroxyapatite nanoparticles (HA-NPs) using Semecarpus anacardium Linn (SAL) leaf extract (termed SAL@HA-NPs) as a capping agent and reducing agent. The presence of needle-shaped nanostructures was verified using SEM and TEM investigation. The presence of well-defined rings in the selected area electron diffraction (SAED) patterns provided evidence for the polycrystalline nature of the SAL@HA-NPs). The XRD spectrum exhibited clear peaks that closely corresponded to the hexagonal patterns of HA, indicating a mean crystalline diameter of 54.25nm. The FTIR analysis revealed the presence of biomolecules from Semecarpus anacardium Linn leaves on the surface of the nanoparticles. The suspension of SAL@HA-NPs displayed a polydispersity index of 0.445 and demonstrated excellent stability, as indicated by the zeta potential of -32.2 mV, as observed in the DLS tests. The SAL@HA-NPs exhibited a harmful effect on the HeLa cervical and HepG2 liver cancer cells, with an IC50 value of 52g/mL. Fluorescence microscopy revealed the deformation of the damaged cell membrane, fragmentation, and cell death following treatment with SAL@HA-NPs. The Annexin V-FITC and PI staining confirmed the mode of apoptosis by flow cytometric analysis. Thus, the SAL@HA-NPs acquired in this study could have a crucial impact on the biomedical domain of cancer treatment. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Subject The topic of the resource Anticancer activity; Apoptosis; Green fabrication; Hydroxyapatite Publisher An entity responsible for making the resource available Springer Relation A related resource ISSN: 15741443; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online