Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Mushtaq, Zahi; Sharma, Vijay; Mukherjee, Jonaki; Wunnava, Aneesh; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A. Title A name given to the resource Carboxymethyl Cellulose-Modified Strontium Oxide Nanoparticles: a Multifunctional Nanoplatform for C6 Glioma Therapy and Antimicrobial Applications Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Journal of Inorganic and Organometallic Polymers and Materials;Volume;35;Issue;12;pp.10290-10305 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s10904-025-03918-x" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s10904-025-03918-x</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105009633228?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105009633228?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Mushtaq Z., Department of Mechanical Engineering, Presidency University, Karnataka, Bengaluru, India; Sharma V., Department of Pharmaceutics, SGT College of Pharmacy, SGT University, Haryana, Gurugram, India; Mukherjee J., Department of Electrical &amp; Electronics, ARKA JAIN University, Jharkhand, Jamshedpur, India; Wunnava A., Electronics and Communication Engineering Department, Siksha O Anusandhan (Deemed to be University, Odisha, Bhubaneswar, 751030, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia Description An account of the resource Glioma, a very aggressive brain tumor, poses major therapeutic challenges. The present research investigates the synthesis, characterization, and bioevaluation of carboxymethyl cellulose (CMC)-functionalized strontium oxide (SrO) nanoparticles (SrCMC) as anticancer and biocompatibility probes. SrO nanoparticles were synthesized using co-precipitation and functionalized with CMC for better dispersion and stability. Characterization by XRD, FTIR, UVVis, PL, SEM, TEM, and EDAX proved structural and optical enhancements. SrCMC showed enhanced photoluminescence with a blue shift and increased emission intensity, indicating modified surface defects. UVVis analysis revealed a slight band gap increase from 4.07eV to 4.12eV due to CMC capping. FTIR and EDAX confirmed successful functionalization, while XRD showed reduced crystallite size (32nm to 26nm) and maintained tetragonal structure. SEM and HRTEM revealed improved dispersion and decreased lattice spacing in SrCMC, reflecting surface stabilization by CMC. For in vitro tests on C6 glioma cells, the cytotoxicity was found to be time- and dose-dependent with IC?? values of 22.1, 17.6, and 14.8g/mL for SrO and 20.3, 15.8, and 12.6g/mL for SrCMC after 24, 48, and 72h respectively. In vivo biocompatibility was assessed using zebrafish embryos exposed to SrCMC nanoparticles at 0.5mg/mL and 1mg/mL across various time intervals. The agar well diffusion method was employed to assess the antimicrobial activity against the following pathogens including Gram-positive (S. pneumoniae, B. subtilis), Gram-negative (K. pneumoniae, S. dysenteriae), and fungal (C. albicans) strains. The results revealed SrCMC exhibited significant inhibitory effects against all tested organisms and comparable to streptomycin. This work shows SrCMCs potential for biomedical applications, subject to careful control of toxicity. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. Subject The topic of the resource Bioevaluation; Characterization; CMC-SrO nanoparticles; Synthesis; Zebrafish Publisher An entity responsible for making the resource available Springer Relation A related resource ISSN: 15741443; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online