Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Thangavelu, Indumathi; Tadepalli, Srinivas; Gadallah, Abdelrahman G. Title A name given to the resource Multifunctional Evaluation of CaCO3Sodium Alginate Nanocomposite for Antibacterial, Antifungal, and Anticancer Applications Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Journal of Inorganic and Organometallic Polymers and Materials; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s10904-026-04325-6" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s10904-026-04325-6</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105038584499?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105038584499?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Gadallah A.G., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia Description An account of the resource In this study, Calcium carbonate (CaCO?) nanoparticles and calcium carbonatesodium alginate (CaCO?SA) nanocomposite were successfully synthesized via a controlled precipitation method and evaluated for multifunctional biomedical applications. Structural and surface analyses confirmed the formation of a calcite phase with effective surface functionalization using SA. The nanocomposite exhibited reduced crystallite size (~ 29nm vs. ~38nm for CaCO?), improved dispersion, and enhanced defect density, as evidenced by XRD, DLS, PL, and TEM analyses. PL studies revealed multiple defect-related emission bands (370534nm), indicating the presence of active surface states. The CaCO?SA nanocomposite demonstrated significantly enhanced antimicrobial activity compared to CaCO?, with zone of inhibition values reaching ~ 20mm (S. aureus), ~ 21mm (S. pneumoniae), ~ 20mm (E. coli), and ~ 18mm (C. albicans), comparable to standard drugs. CFU analysis confirmed a concentration-dependent reduction in bacterial viability, while MIC and MBC values were reduced to 500g mL? and 750g mL?, respectively, indicating improved bacteriostatic and bactericidal efficiency. In anticancer studies, the nanocomposite exhibited enhanced cytotoxicity against MG-63 osteosarcoma cells, reducing cell viability to ~ 30% at higher concentrations, while maintaining high biocompatibility of &gt; 80% viability toward L929 fibroblast cells. Overall, this work highlights the potential of surface engineered CaCO? based nanomaterials as promising candidates for combined antimicrobial and anticancer applications, providing a foundation for future in-depth biological investigations and translational studies. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026. Subject The topic of the resource Anticancer activity; Antimicrobial activity; CaCO₃ nanoparticles; Nanocomposite; SA Publisher An entity responsible for making the resource available Springer Relation A related resource ISSN: 15741443; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online