Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Roopashree, R.; Gupta, Anchal; Rathore, Mahendra Singh; Sharma, Kamini; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Ramar, Mohankumar; Kalaiarasi, Giriraj; Thangavelu, Indumathi; Suriyaprakash, Jagadeesh Title A name given to the resource Fabrication of Kaempferol Loaded Zein Nanoparticles: Investigation of in Vitro Cytotoxicity and Apoptosis Induction in Oral Cancer Cells Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Journal of Polymers and the Environment;Volume;33;Issue;5;pp.2371-2384 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s10924-025-03532-5" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s10924-025-03532-5</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105003288709?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105003288709?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Roopashree R., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, 560069, India; Gupta A., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Rathore M.S., Department of Applied Science, PIT, Parul University, Gujarat, Vadodara, 391760, India; Sharma K., Department of Sciences, Vivekananda Global University, Jaipur, 303012, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, PO Box - 2455, Riyadh, 11451, Saudi Arabia; Alharbi S.A., Department of Botany and Microbiology, College of Science, King Saud University, PO Box - 2455, Riyadh, 11451, Saudi Arabia; Ramar M., Department of Pharmacology and Toxicology, School of Pharmacy, University of Connecticut, Storrs, CT, United States; Kalaiarasi G., Centre for Material Chemistry, Department of Chemistry, Karpagam Academy of Higher Education, Tamil Nadu, Coimbatore, 641 021, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Suriyaprakash J., Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter, Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China Description An account of the resource Oral cancer remains a significant health challenge, necessitating innovative therapeutic strategies to enhance treatment efficacy and minimize side effects. This study investigates the potential of kaempferol-loaded zein nanoparticles (KZNPs) for this purpose. Kaempferol, a flavonoid with anticancer properties, has poor water solubility, limiting its effectiveness. Zein nanoparticles (ZNPs) offer a promising delivery system for such bioactive compounds. UV-Vis spectroscopy identified Kaempferols absorption peaks at 347 and 253nm, which shifted to 338nm when encapsulated in ZNPs, indicating a change in ??* conjugation. Dynamic light scattering (DLS) and scanning electron microscopy (SEM) confirmed that sodium caseinate (SC) stabilizes ZNPs, resulting in spherical particles with optimal size and stability. Fourier transform infrared (FTIR) spectroscopy suggested enhanced hydrogen bonding between Kaempferol and zein. Differential scanning calorimetry (DSC) revealed the absence of Kaempferols crystalline peaks in KZNPs. The encapsulation efficiency (EE) was 98.39%, and drug release studies showed a controlled release of 79% kaempferol over 8h. In vitro assays demonstrated that KZNPs significantly increased Kaempferols cytotoxicity against PCI-13 oral cancer cells without affecting normal NIH3T3 cancer cells. Overall, these results demonstrate that our KZNPs enhanced biocompatibility and anticancer properties for oral cancer cells. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. Subject The topic of the resource Apoptosis; Cytotoxicity; Kaempferol; Oral cancer; Zein Publisher An entity responsible for making the resource available Springer Relation A related resource ISSN: 15662543; CODEN: JPENF Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online