Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Pant, Shubham; Manoj, Nayana Soosan; Ramchandran, Anupama; Thomas, Sabu; Loganathan, Sravanthi; Valapa, Ravi Babu Title A name given to the resource Comparative Evaluation of Curcumin Derivatives Loaded 3D Printable Chitosan/Gelatin Hydrogels: Release Behaviour, Antimicrobial, Antioxidant, and Immunomodulatory Properties Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Journal of Polymers and the Environment;Volume;33;Issue;12;pp.5289-5314 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s10924-025-03706-1" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s10924-025-03706-1</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105021355071?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105021355071?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pant S., Electrochemical Process Engineering Division, CSIR-Central Electrochemical Research Institute (CECRI), Tamil Nadu, Karaikudi, 630003, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; Manoj N.S., Central Institute of Petrochemical Engineering and Technology (CIPET)-IPT, Cochin University of Science and Technology (CUSAT), Kerala, Kochi, 683501, India; Ramchandran A., Central Institute of Petrochemical Engineering and Technology (CIPET)-IPT, Cochin University of Science and Technology (CUSAT), Kerala, Kochi, 683501, India; Thomas S., School of Chemical Sciences, Mahatma Gandhi University, Kerala, Kottayam, 686560, India, Department of Physics &amp; Electronics, CHRIST (Deemed to be University), Bangalore, India, Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg, 2028, South Africa; Loganathan S., Electrochemical Process Engineering Division, CSIR-Central Electrochemical Research Institute (CECRI), Tamil Nadu, Karaikudi, 630003, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; Valapa R.B., Electrochemical Process Engineering Division, CSIR-Central Electrochemical Research Institute (CECRI), Tamil Nadu, Karaikudi, 630003, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India Description An account of the resource The development of multifunctional scaffolds with improved mechanical strength, swelling resistance, antibacterial activity and cytocompatibility is crucial for tissue engineering. In this study, chitosangelatin (CH GT) scaffolds were reinforced with curcumin (Cur), nano-curcumin (nCur), and PLGA-encapsulated curcumin (PLGA_Cur) to enhance physicochemical and biological properties. SEM micrographs confirmed uniform, interconnected pores with reduced pore wall disruption upon Cur incorporation. Mechanical testing revealed that the highest tensile strength and tensile modulus for CH GT nCur were observed at 34kPa and 58kPa, respectively. Swelling studies showed a significant reduction in equilibrium swelling ratio from ~ 675% (CH GT) to ~ 340% (CH GT_nCur), correlating with enhanced hydrogen bonding and physical crosslinking. Antibacterial assays indicated significant inhibition against S. aureus (~ 94%) and E. coli (~ 92%) for CH GT_nCur. Cytocompatibility tests showed &gt; 85% cell viability across all formulations, with CH GT_nCur supporting superior cell attachment and cell migration capabilities compared to controls. Cur release from CH GT Cur and CH GT nCur hydrogel scaffolds resulted in antioxidant activity; however it was slightly impeded by rapid release. In the PLGA-based system, antioxidant activity is enhanced with sustained release. CH GT Cur and CH GT nCur enhanced M2 macrophage polarization (p &lt; 0.001) compared to CH GT Cur hydrogels, which successfully decreased inflammation and oxidative stress. Notably, despite a delayed M2 response, the PLGA-encapsulated Cur system (CH GT PLGA_Cur) demonstrated sustained decrease of ROS levels and iNOS expression, suggesting extended anti-inflammatory effect. These results demonstrate the promise of CH GT-based hydrogels, particularly the PLGA_Cur system, for oxidative stress management and regulated immunomodulation in therapeutic settings. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. Subject The topic of the resource 3D printing; Anti-inflammatory; Antioxidant activity; Chitosan; Curcumin derivatives; Gelatin; Wound healing Publisher An entity responsible for making the resource available Springer Relation A related resource ISSN: 15662543; CODEN: JPENF Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online