Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Wei, Yan; Li, Qi; Hirad, Abdurahman Hajinur; Alarfaj, Abdullah A.; Thangavelu, Indumathi; Arulselvan, Palanisamy Title A name given to the resource Evaluation of the Neuroprotective Efficacies and Related Mechanisms of Cirsimaritin in MPTP-Induced Parkinson in Mice with Following the Molecular Docking Studies Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived Journal of Pharmaceutical Innovation;Volume;21;Issue;3;Article No.;244; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s12247-025-10345-5" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s12247-025-10345-5</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105031736329?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105031736329?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Wei Y., Department of Encephalopathy, Xian Hospital of Traditional Chinese Medicine, Xian, China; Li Q., Department of Encephalopathy, Xian Hospital of Traditional Chinese Medicine, Xian, China; Hirad A.H., Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box. 2455, 11451, Riyadh, Saudi Arabia; Alarfaj A.A., Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box. 2455, 11451, Riyadh, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, India; Arulselvan P., Department of Biochemistry, Karpagam Academy of Higher Education (Deemed to be University), Tamilnadu, Coimbatore, 641021, India Description An account of the resource Parkinsons disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss and oxidative stressinduced apoptosis. The present study evaluated the neuroprotective potential of cirsimaritin against MPTP-induced PD in mice and explored its possible mechanism through combined in silico and in vivo approaches. Molecular docking using AutoDock Vina revealed that cirsimaritin exhibits strong binding affinities with key antioxidant enzymes (CAT, GPx, and SOD) and apoptosis-related proteins (Bcl-2, Bax, caspase-3, ?8, and ? 9), suggesting possible modulation of oxidative and apoptotic signaling pathways. In vivo, PD was induced by MPTP (30mg/kg, i.p., for 7days), followed by oral administration of cirsimaritin (25 and 50mg/kg). Behavioral assessmentsincluding the open field, narrow beam walking, and wire hanging testsdemonstrated significant improvement in locomotor and neuromuscular performance in cirsimaritin-treated mice. Biochemical analyses revealed that cirsimaritin restored dopamine and its metabolites, decreased lipid peroxidation (TBARS), and enhanced antioxidant enzyme activities (CAT, SOD, and GPx). Additionally, cirsimaritin attenuated apoptosis by upregulating Bcl-2 and downregulating Bax and caspase-3 expression. Histopathological examination confirmed reduced neurodegeneration in the brain hippocampus of treated mice. These findings indicate that cirsimaritin exerts potent neuroprotective effects in MPTP-induced PD mice, likely through its antioxidant and anti-apoptotic actions, supporting its potential as a therapeutic candidate for Parkinsons disease. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026. Subject The topic of the resource Apoptosis; Cirsimaritin; Dopamine; Neurodegeneration; Oxidative stress Publisher An entity responsible for making the resource available Springer Relation A related resource ISSN: 18725120; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online