Biological and Environmental Applications of Myco-synthesized Titanium Dioxide Nanoparticles
Anti-diabetic; Anti-inflammatory; Antibacterial; Antioxidant; Endophytic fungi; Photocatalytic degradation; Remediation; Titanium dioxide nanoparticles
In the present investigation, TiO2NPs were myco-synthesized through the extracellular enzymes of endophytic fungi, Aspergillus versicolor FCPRS11 isolated from stem of Azadirachta indica. The synthesized TiO2NPs was characterized using UV- Vis, FT-IR, SEM, XRD, EDX, DLS and Zeta Potential. The synthesized TiO2NPs were analyzed for their antimicrobicidal properties against five clinical pathogens with two fungal pathogens and were exhibiting significant inhibition towards the bacteria at minimum concentration of 50g/ml of TiO2NPs. The free radical scavenging mechanism of the synthesized TiO2NPs was monitored through various assessment to understand about NPs antioxidant properties and the IC50 values were compared with the IC50 value of standard ascorbic acid (91g/ml). Further the NPs were analyzed for in vitro anti- inflammatory property exhibiting 73.87% inhibition and anti- diabetic properties (62.18% inhibition) proving that TiO2NPs evinced a promising biomedical activity. The larger surface area of the synthesized TiO2NPs as per the SEM analysis, allowed evaluation of their adsorption capacity on soil collected from metallurgical site containing combination of heavy metals and contaminants. The results of adsorption studies demonstrated that the adsorption increases with increase in time of exposure of TiO2NPs and adsorption capacity was determined by employing Langmuir model. The % dye degradation was evaluated by photocatalytic dye degradation studies where at 100mg/L of TiO2NPs, over 91% dye was found to be degraded within 240mins.These findings highlight the potential of myco-synthesized TiO?NPs as effective agents for biomedical applications and environmental nanoremediation. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
Radhakrishnan, Sruthi; Ganesan, Vijiyakumar; Paramasivam, Deepak; Umesh, Mridul; Mani, Vellingiri Manon
BioNanoScience;Volume;16;Issue;1;Article No.;31;
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https://doi.org/10.1007/s12668-025-02252-3 https://www.scopus.com/pages/publications/105025194676?origin=resultslist
Radhakrishnan S., Department of Biotechnology, RVS College of Arts and Science, Tamil Nadu, Coimbatore, 641402, India; Ganesan V., Department of Biotechnology, RVS College of Arts and Science, Tamil Nadu, Coimbatore, 641402, India; Paramasivam D., Department of Life Sciences, School of Biological & Forensic Sciences, Kristu Jayanti (Deemed-to-be University), Karnataka, Bengaluru, 560077, India; Umesh M., Department of Life Sciences, Christ University, Karnataka, Bengaluru, India; Mani V.M., Department of Life Sciences, School of Biological & Forensic Sciences, Kristu Jayanti (Deemed-to-be University), Karnataka, Bengaluru, 560077, India