Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Goyal, Prakhar; Ballal, Suhas; Saini, Ramesh; Awasthi, Kumud Kant; Dhingra, Lovish; Pund, Sachin S.; Thangavelu, Indumathi; Tadepalli, Srinivas Title A name given to the resource Synthesis and Biological Evaluation of Sr and Co Co-Doped TiO?Folic Acid Nanocomposites: Antibacterial, Antifungal (Candida albicans), Antioxidant (DPPH and Trolox), and In Vitro Anticancer Activity against HepG2 Cells Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived BioNanoScience;Volume;16;Issue;5;Article No.;322; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s12668-026-02562-0" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s12668-026-02562-0</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105037918754?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105037918754?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Goyal P., Quantum University Research Center, Quantum University, Uttarakhand, Roorkee, 247667, India; Ballal S., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, 560002, India; Saini R., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Awasthi K.K., Department of Sciences, Vivekananda Global University, Jaipur, 303012, India; Dhingra L., Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, 174103, India; Pund S.S., Department of Industrial Engineering, Shri Ramdeobaba College of Engineering and Management, Maharashtra, Nagpur, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia Description An account of the resource Liver cancer and multidrug-resistant bacterial infections pose significant health challenges, highlighting the urgent need for multifunctional therapeutics. In this study, a TiO? nanocomposite co-doped with strontium (Sr) and cobalt (Co) and surface-functionalized with folic acid (TiO?SrCoFA) nanocomposite was synthesized via a hydrothermal method followed by post-synthesis FA functionalization. XRD confirmed the anatase phase, with reduced crystallite size for TiO?SrCoFA, while TEM showed spherical, uniformly dispersed nanoparticles (~ 23nm) with no agglomeration. DLS revealed a hydrodynamic diameter of 138.6nm, and XPS/FTIR confirmed Sr, Co, and FA incorporation. Optical studies (UV-Vis and PL) indicated electronic modifications conducive to ROS generation. TiO?SrCoFA exhibited enhanced antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, Bacillus megaterium), Gram-negative bacteria (Klebsiella pneumoniae, Proteus vulgaris), and Candida albicans. Antioxidant assays demonstrated concentration-dependent scavenging (2883%) comparable to vitamin C. In HepG2 liver cancer cells, TiO?SrCoFA showed superior cytotoxicity with an IC?? of 6.5g/mL versus 9.8g/mL for TiO?, inducing apoptosis and oxidative stress. The enhanced bioactivity is attributed to nanoscale size, Sr/Co doping, FA-mediated targeting, and ROS generation. TiO?SrCoFA thus represents a promising multifunctional nanotherapeutic platform for simultaneous antimicrobial, antioxidant, and anticancer applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026. Subject The topic of the resource Folic acid functionalisation; Hydrothermal synthesis; Liver cancer HePG-2 cells; Sr and Co co-doped; TiO?SrCoFA Publisher An entity responsible for making the resource available Springer Relation A related resource ISSN: 21911630; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online