Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Mathew, Gicy; Amruth, P. Title A name given to the resource Chitosan Coated-Liposomal Microencapsulation of Fucoidan Extracted from Marine Sargassum wightii: Assessment of Its Biofunctional and Therapeutic Properties Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2026 Source A related resource from which the described resource is derived BioNanoScience;Volume;16;Issue;5;Article No.;340; Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s12668-026-02572-y" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s12668-026-02572-y</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105038183590?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105038183590?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Mathew G., Department of Life Sciences, Christ University, Bangalore, 560029, India; Amruth P., Department of Life Sciences, Christ University, Bangalore, 560029, India, Centre for Landscapes, Wildlife and Marine Ecology (CLIME), Christ University, Bangalore, 560029, India Description An account of the resource Fucoidan, a sulphated polysaccharide derived from Sargassum wightii, holds significant therapeutic potential due to its antioxidant, antimicrobial, and wound-healing properties. Despite its therapeutic properties, its clinical efficacy is limited by poor bioavailability and instability. This study reports the successful encapsulation of fucoidan in liposomes employing the thin-film hydration technique, followed by chitosan coating to enhance its stability and biological activity. Structural integrity and successful encapsulation were confirmed through FTIR and UVVis spectroscopy. Antioxidant activity assessed via DPPH and hydrogen peroxide scavenging assays demonstrated concentration-dependent radical scavenging, with chitosan-coated formulations exhibiting superior efficacy. The formulation was reported to exhibit strong antioxidant potential, as indicated by DPPH (38.65% at 500?g/ml) and H?O? (40.707% at 400 ?g/ml). Antimicrobial testing revealed notable activity against the Gram-negative bacterium Escherichia coli, but not against the Gram-positive bacterium Bacillus subtilis, suggesting a narrow-spectrum antibacterial potential. The antimicrobial assays conducted reported a zone of inhibition of 11.4mm for a concentration of 2mg/ml. Furthermore, scratch wound assays and MTT-based cytotoxicity analysis on L929 fibroblast cells indicated promising wound-healing activity, with a wound closure of 92.72% observed 72h after treatment with the sample. The IC?? value of 100?g/ml was also reported to have high cell viability of 84.22%. These findings underscore the potential of chitosan-coated liposomal fucoidan as a multifunctional bioactive system for pharmaceutical and biomedical applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026. Subject The topic of the resource Antioxidant; Chitosan; Cytotoxicity; Fucoidan; Micro-encapsulation; Mouse L929 fibroblast; Sargassum wightii; Wound-healing Publisher An entity responsible for making the resource available Springer Relation A related resource ISSN: 21911630; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource Restricted Access; Hardcopy may be available in the library Format The file format, physical medium, or dimensions of the resource online