Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Faculty Publications Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Sunil, Karthika; Thomas, Tinu Title A name given to the resource In-silico analysis of the mechanism of action ofNerium oleanderbioactive compounds againstHelicoverpa armigera Date A point or period of time associated with an event in the lifecycle of the resource 01-01-2025 Source A related resource from which the described resource is derived Advanced Agrochem;Volume;4;Issue;4;pp.336-341 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.aac.2025.09.001" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.aac.2025.09.001</a> <br /><br /><a href="https://www.scopus.com/pages/publications/105017600890?origin=resultslist" target="_blank" rel="noreferrer noopener">https://www.scopus.com/pages/publications/105017600890?origin=resultslist</a> Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Sunil K., Department of Life Sciences, Christ University, Bangalore, India; Thomas T., Department of Life Sciences, Christ University, Bangalore, India, Centre for Landscapes, Wildlife and Marine Ecology (CLIME), Department of Life Sciences, Christ University, Bangalore, India Description An account of the resource Helicoverpa armigera is one of the most destructive agricultural pests worldwide, noted for its wide host range, high fecundity, and rapid development of resistance to synthetic insecticides. To address this threat, sustainable botanical alternatives are urgently needed. In this study, Nerium oleander, a toxic ornamental plant rich in secondary metabolites, was evaluated as a potential botanical insecticide through in silico assays. Methanolic extracts were subjected to phytochemical screening, confirming the presence of alkaloids, saponins, cardiac glycosides, coumarins, and terpenoids. Gas Chromatography-Mass Spectrometry (GC-MS) profiling identified 20 major compounds, including terpenoids, fatty acids, sterols, and phenolics, with 2-methoxy-4-vinylphenol (2.7 %), neophytadiene (1.7 %), and phytol (0.9 %) among the key constituents. Cytochrome P450, a central detoxification enzyme in insects, was chosen as the molecular target. Docking analysis revealed strong binding affinities, with phytol (?6.92 kcal/mol, Ki 8.12 ?M), neophytadiene (?6.43 kcal/mol, Ki 14.57 ?M), and 2-methoxy-4-vinylphenol (?5.87 kcal/mol, Ki 45.13 ?M) demonstrating significant inhibitory potential. These findings indicate that N. oleander metabolites may disrupt detoxification pathways in H. armigera, providing a mechanistic basis for their insecticidal action and supporting the plant's promise as a candidate for integrated pest management. 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. LtdThis is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/ Subject The topic of the resource Bollworm; Botanical insecticide; Cotton; Metabolite profiling; Molecular docking Publisher An entity responsible for making the resource available KeAi Communications Co. Relation A related resource ISSN: 27732371; Language A language of the resource English Type The nature or genre of the resource Article Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Format The file format, physical medium, or dimensions of the resource online